Chagas, disease, molecular biology, immunology of Trypanosoma cruzi - Jose O'Daly
Five mitogenic proteins in FCS stimulate T. cruzi division, found in plasma membranes and cytoplasmic granules, changed structure by T. cruzi growth, base of autoimmunity. Insoluble fraction from T. cruzi membranes lysed cells, it is a lipid, pronase, trypsin, temperature resistant, inhibited by albumin. Inhibition of T. cruzi¿s proteolytic activity, key for vaccines¿ production. Synthetic medium, allowed T cruzi growth between 26°- 37°C, with FCS or peptides of glutamic acid, alanine and lysine...