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Country-Level Decision Making for Control of Chronic Diseases - Board On Global Health - Bog - National Academies Press - Plusbog.dk

Country-Level Decision Making for Control of Chronic Diseases - Board On Global Health - Bog - National Academies Press - Plusbog.dk

A 2010 IOM report, Promoting Cardiovascular Health in the Developing World, found that not only is it possible to reduce the burden of cardiovascular disease and related chronic diseases in developing countries, but also that such a reduction will be critical to achieving global health and development goals. As part a series of follow-up activities to the 2010 report, the IOM held a workshop that aimed to identify what is needed to create tools for country-led planning of effective, efficient, and equitable provision of chronic disease control programs. Table of ContentsFront Matter1 Introduction2 Progress, Needs, and Lessons Learned: Perspectives from Six Countries3 Data Availability and Gaps in Four Countries4 Examples of Tools for Costing, Economic Modeling, and Priority Setting5 Approaches to Supporting Country-Led Action6 Summary of Considerations for Developing a Toolkit for Country-Led Decision MakingReferencesAppendix A: Workshop AgendaAppendix B: Biographies

DKK 260.00
1

International Collaborations in Behavioral and Social Sciences Research - Committee On International Collaborations In Behavioral And Social Sciences

International Collaborations in Behavioral and Social Sciences Research - Committee On International Collaborations In Behavioral And Social Sciences

Based on the outcomes of a workshop convened by the US National Committee for Psychological Science and informed by a survey of social scientists who have led cross-national projects, this report addresses the multiple benefits of research extending across national boundaries and describes factors common among successful collaborations.

DKK 260.00
1

Community Power in Population Health Improvement - Board On Population Health And Public Health Practice - Bog - National Academies Press - Plusbog.dk

Community Power in Population Health Improvement - Board On Population Health And Public Health Practice - Bog - National Academies Press - Plusbog.dk

To explore issues related to community-driven power-building efforts to improve population health, the Roundtable on Population Health Improvement of the National Academies of Sciences, Engineering, and Medicine hosted a virtual public workshop, "Community Power in Population Health Improvement", on January 28 and 29, 2021. Participants discussed the different components and dimensions of community-led action around different population health improvement topics such as education, transportation, environmental health, healthy eating, and active living, among others. This Proceedings of a Workshop summarizes the presentations and discussion of the workshop. Table of ContentsFront Matter1 Introduction2 Daring to Lead3 Community Power in the Context of Population Health4 Community Power: Approaches and Models5 From Vision to Action: Effective Ways to Support Grassroots Community Power Building6 Community-Led Transformational Narratives7 Amplifying the Empirical Base Linking Community Power and Health EquityAppendix A: ReferencesAppendix B: Biosketches of Speakers, Moderators, and Planning Committee MembersAppendix C: Workshop AgendaAppendix D: Readings and Resources

DKK 214.00
1

Antibiotic Resistance - Board On Global Health - Bog - National Academies Press - Plusbog.dk

Antibiotic Resistance - Board On Global Health - Bog - National Academies Press - Plusbog.dk

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs. Table of ContentsFront MatterWorkshop OverviewAppendix A: Contributed ManuscriptsAppendix B: AgendaAppendix C: AcronymsAppendix D: GlossaryAppendix E: Forum Member BiographiesAppendix F: Speaker Biographies

DKK 578.00
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The Drug Development Paradigm in Oncology - Health And Medicine Division - Bog - National Academies Press - Plusbog.dk

The Drug Development Paradigm in Oncology - Health And Medicine Division - Bog - National Academies Press - Plusbog.dk

Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of efforts—by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)—to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop. Table of ContentsFront MatterProceedings of a WorkshopAppendix A: Statement of TaskAppendix B: Workshop Agenda

DKK 344.00
1

Assessment of Solid-State Lighting, Phase Two - Board On Energy And Environmental Systems - Bog - National Academies Press - Plusbog.dk

Assessment of Solid-State Lighting, Phase Two - Board On Energy And Environmental Systems - Bog - National Academies Press - Plusbog.dk

The standard incandescent light bulb, which still works mainly as Thomas Edison invented it, converts more than 90% of the consumed electricity into heat. Given the availability of newer lighting technologies that convert a greater percentage of electricity into useful light, there is potential to decrease the amount of energy used for lighting in both commercial and residential applications. Although technologies such as compact fluorescent lamps (CFLs) have emerged in the past few decades and will help achieve the goal of increased energy efficiency, solid-state lighting (SSL) stands to play a large role in dramatically decreasing U.S. energy consumption for lighting. Since the publication of the 2013 National Research Council report Assessment of Advanced Solid-State Lighting, the penetration of SSL has increased dramatically, with a resulting savings in energy and costs that were foreshadowed by that study. What was not anticipated then is the dramatic dislocation and restructuring of the SSL marketplace, as cost reductions for light-emitting diode (LED) components reduced profitability for LED manufacturers. At the same time, there has been the emergence of new applications for SSL, which have the potential to create new markets and commercial opportunities for the SSL industry. Assessment of Solid-State Lighting, Phase Two discusses these aspects of change—highlighting the progress of commercialization and acceptance of SSL and reviewing the technical advances and challenges in achieving higher efficacy for LEDs and organic light-emitting diodes. This report will also discuss the recent trends in SSL manufacturing and opportunities for new applications and describe the role played by the Department of Energy (DOE) Lighting Program in the development of SSL. Table of ContentsFront MatterSummary1 Introduction2 Public Policy and Deployment of New Lighting Technologies3 Assessment of LED and OLED Technologies4 SSL Applications5 ManufacturingAppendixesAppendix A: Committee Biographical InformationAppendix B: Committee Meetings and PresentationsAppendix C: Nomenclature and DefinitionsAppendix D: Acronyms and Abbreviations

DKK 396.00
1

Allied Health Workforce and Services - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Allied Health Workforce and Services - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

The demand for health care is growing as the nation ages and seeks to provide coverage for the millions of Americans who lack health insurance. At the same time, escalating costs have led to a variety of initiatives to make the delivery of health care more effective and efficient. The allied health workforce is critical to the success of these efforts. The IOM held a workshop May 9-10, 2011, to examine the current allied health care workforce and consider how it can contribute to improving health care access, quality, and effectiveness.

DKK 266.00
1

Protecting Those Who Serve - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Protecting Those Who Serve - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Since the Gulf War ended in 1991, various constituencies, including a significant number of veterans, speculate that unidentified risk factors led to chronic, medically unexplained illnesses, and these constituencies challenge the depth of the military's commitment to protect the health of deployed troops. Despite general concurrence in findings to support these claims, few changes have been made at the field level. The most important recommendations remain unimplemented, despite the compelling rationale for urgent action. Protecting Those Who Serve illuminates these recommendations and government-developed plans that remain inactive due to a lack of authority within the Department of Defense, while describing the dangers that may result from failure to protect our forces in the field.

DKK 292.00
1

Innovation in Cancer Care and Cancer Research in the Context of the COVID-19 Pandemic - Health And Medicine Division - Bog - National Academies Press

Innovation in Cancer Care and Cancer Research in the Context of the COVID-19 Pandemic - Health And Medicine Division - Bog - National Academies Press

The COVID-19 pandemic has led to dramatic adjustments in cancer care delivery and cancer research. To examine these changes, the National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine convened a virtual workshop, Innovation in Cancer Care and Cancer Research in the Context of the COVID-19 Pandemic, in July 2021. Workshop speakers considered the lessons learned from these adaptations in order to improve the delivery of high-quality cancer care and the conduct of cancer clinical trials in the post-pandemic era. This Proceedings of a Workshop highlights presentations and discussions from the workshop. Table of ContentsFront MatterProceedings of a WorkshopAppendix A: Statement of TaskAppendix B: Workshop Agenda

DKK 240.00
1

Adolescent Decision Making - National Research Council And Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Adolescent Decision Making - National Research Council And Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Interest in the role that decision making plays in adolescents' involvement in high-risk behaviors led the Office of the Assistant Secretary of Planning and Evaluation of the U.S. Department of Health and Human Services to request the Board on Children, Youth, and Families to convene a workshop on adolescent decision making. The Board on Children, Youth, and Families is a joint activity of the National Research Council (NRC) and the Institute of Medicine. A workshop was held on January 6-7, 1998, to examine what is known about adolescents' decision-making skills and the implications of that knowledge for programs to further their healthy development. Table of ContentsFront MatterAdolescent Decision Making: Implications for Prevention ProgramsReferencesWorkshop Participants

DKK 169.00
1

Genome-Based Therapeutics - Board On Health Sciences Policy - Bog - National Academies Press - Plusbog.dk

Genome-Based Therapeutics - Board On Health Sciences Policy - Bog - National Academies Press - Plusbog.dk

The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many suspected causes for this trend, including increases in regulatory barriers, the rising costs of scientific inquiry, a decrease in research and development efficiency, the downstream effects of patient expirations on investment, and the lack of production models that have successfully incorporated new technology. Regardless, this trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development, whether with other industrial firms, academia, or government. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to reverse the trends highlighted above, while producing more effective drugs in the process. Genome-Based Therapeutics explains that new technologies have the potential to open up avenues of development and to identify new drug targets to pursue. Specifically, improved validation of gene-disease associations through genomics research has the potential to revolutionize drug production and lower development costs. Genetic information has helped developers by increasing their understanding of the mechanisms of disease as well as individual patients' reactions to their medications. There is a need to identify the success factors for the various models that are being developed, whether they are industry-led, academia-led, or collaborations between the two. Genome-Based Therapeutics summarizes a workshop that was held on March 21, 2012, titled New Paradigms in Drug Discovery: How Genomic Data Are Being Used to Revolutionize the Drug Discovery and Development Process. At this workshop the goal was to examine the general approaches being used to apply successes achieved so far, and the challenges ahead. Table of ContentsFront Matter1 Introduction2 The Current Landscape3 Case Studies4 Emerging Technologies in Drug Development5 Evolving Paradigms6 Forging Collaborative Strategies for the Development of Personalized MedicineReferencesAppendix A: Workshop AgendaAppendix B: Speaker Biographical SketchesAppendix C: Statement of TaskAppendix D: Registered Attendees

DKK 247.00
1

Rangeland Heath - National Research Council - Bog - National Academies Press - Plusbog.dk

Rangeland Heath - National Research Council - Bog - National Academies Press - Plusbog.dk

Rangelands comprise between 40 and 50 percent of all U.S. land and serve the nation both as productive areas for wildlife, recreational use, and livestock grazing and as watersheds. The health and management of rangelands have been matters for scientific inquiry and public debate since the 1880s, when reports of widespread range degradation and livestock losses led to the first attempts to inventory and classify rangelands. Scientists are now questioning the utility of current methods of rangeland classification and inventory, as well as the data available to determine whether rangelands are being degraded. These experts, who are using the same methods and data, have come to different conclusions. This book examines the scientific basis of methods used by federal agencies to inventory, classify, and monitor rangelands; it assesses the success of these methods; and it recommends improvements. The book's findings and recommendations are of interest to the public; scientists; ranchers; and local, state, and federal policymakers.

DKK 351.00
1

The Future of Atmospheric Chemistry Research - Committee On The Future Of Atmospheric Chemistry Research - Bog - National Academies Press - Plusbog.dk

The Future of Atmospheric Chemistry Research - Committee On The Future Of Atmospheric Chemistry Research - Bog - National Academies Press - Plusbog.dk

Our world is changing at an accelerating rate. The global human population has grown from 6.1 billion to 7.1 billion in the last 15 years and is projected to reach 11.2 billion by the end of the century. The distribution of humans across the globe has also shifted, with more than 50 percent of the global population now living in urban areas, compared to 29 percent in 1950. Along with these trends, increasing energy demands, expanding industrial activities, and intensification of agricultural activities worldwide have in turn led to changes in emissions that have altered the composition of the atmosphere. These changes have led to major challenges for society, including deleterious impacts on climate, human and ecosystem health. Climate change is one of the greatest environmental challenges facing society today. Air pollution is a major threat to human health, as one out of eight deaths globally is caused by air pollution. And, future food production and global food security are vulnerable to both global change and air pollution. Atmospheric chemistry research is a key part of understanding and responding to these challenges. The Future of Atmospheric Chemistry Research: Remembering Yesterday, Understanding Today, Anticipating Tomorrow summarizes the rationale and need for supporting a comprehensive U.S. research program in atmospheric chemistry; comments on the broad trends in laboratory, field, satellite, and modeling studies of atmospheric chemistry; determines the priority areas of research for advancing the basic science of atmospheric chemistry; and identifies the highest priority needs for improvements in the research infrastructure to address those priority research topics. This report describes the scientific advances over the past decade in six core areas of atmospheric chemistry: emissions, chemical transformation, oxidants, atmospheric dynamics and circulation, aerosol particles and clouds, and biogeochemical cycles and deposition. This material was developed for the NSF's Atmospheric Chemistry Program; however, the findings will be of interest to other agencies and programs that support atmospheric chemistry research. Table of ContentsFront MatterSummary1 Why This Report?2 Remembering Yesterday3 Understanding Today4 Anticipating Tomorrow: Societal Challenges5 Anticipating Tomorrow: Research Priorities in Atmospheric Chemistry6 Recommended Supporting Programmatic and Infrastructure Priorities for Advancing Atmospheric Chemistry Research7 Final ThoughtsReferencesAppendix A: Committee BiographiesAppendix B: Community Input GatheringAppendix C: Analysis of Funding Trends for Atmospheric Chemistry Research

DKK 364.00
1

Riparian Areas - Committee On Riparian Zone Functioning And Strategies For Management - Bog - National Academies Press - Plusbog.dk

Riparian Areas - Committee On Riparian Zone Functioning And Strategies For Management - Bog - National Academies Press - Plusbog.dk

The Clean Water Act (CWA) requires that wetlands be protected from degradation because of their important ecological functions including maintenance of high water quality and provision of fish and wildlife habitat. However, this protection generally does not encompass riparian areas—the lands bordering rivers and lakes—even though they often provide the same functions as wetlands. Growing recognition of the similarities in wetland and riparian area functioning and the differences in their legal protection led the NRC in 1999 to undertake a study of riparian areas, which has culminated in Riparian Areas: Functioning and Strategies for Management. The report is intended to heighten awareness of riparian areas commensurate with their ecological and societal values. The primary conclusion is that, because riparian areas perform a disproportionate number of biological and physical functions on a unit area basis, restoration of riparian functions along America's waterbodies should be a national goal. Table of ContentsFront MatterSUMMARY1 INTRODUCTION2 STRUCTURE AND FUNCTIONING OF RIPARIAN AREAS3 HUMAN ALTERATIONS OF RIPARIAN AREAS4 EXISTING LEGAL STRATEGIES FOR RIPARIAN5 MANAGEMENT OF RIPARIAN AREASAPPENDIX A: COMMITTEE MEMBER AND STAFF BIOGRAPHIESCOLOR PLATES

DKK 422.00
1

America's Future in Space - Aeronautics And Space Engineering Board - Bog - National Academies Press - Plusbog.dk

America's Future in Space - Aeronautics And Space Engineering Board - Bog - National Academies Press - Plusbog.dk

As civil space policies and programs have evolved, the geopolitical environment has changed dramatically. Although the U.S. space program was originally driven in large part by competition with the Soviet Union, the nation now finds itself in a post-Cold War world in which many nations have established, or are aspiring to develop, independent space capabilities. Furthermore discoveries from developments in the first 50 years of the space age have led to an explosion of scientific and engineering knowledge and practical applications of space technology. The private sector has also been developing, fielding, and expanding the commercial use of space-based technology and systems. Recognizing the new national and international context for space activities, America's Future in Space is meant to advise the nation on key goals and critical issues in 21st century U.S. civil space policy. Table of ContentsFront MatterSummary1 From Sputnik and Apollo to Today's Globalized Environment2 Goals for U.S. Civil Space Activities3 Foundational Elements4 RecommendationsAppendixesAppendix A: Committee Member and Staff BiographiesAppendix B: Statement of TaskAppendix C: Meeting AgendasAppendix D: Committee Outreach and Public Responses

DKK 266.00
1

Attracting Science and Mathematics Ph.D.s to Secondary School Education - Policy And Global Affairs - Bog - National Academies Press - Plusbog.dk

Attracting Science and Mathematics Ph.D.s to Secondary School Education - Policy And Global Affairs - Bog - National Academies Press - Plusbog.dk

The National Research Council conducted a study to identify a set of incentives that state governments and local school districts can use to attract Ph.D. scientists and mathematicians to secondary school teaching positions. This project investigated the career ambitions of Ph.D.s in the physical and life sciences through focus groups and a national survey to determine the kinds of work conditions and compensation packages that would induce them to take positions teaching physics, chemistry, biology, and various electives in public high schools or positions developing secondary school science and mathematics curricula. The study conducted interviews with Ph.D.s who are already teaching in secondary schools to ascertain information from their experiences, with local school district administrators to assess what they are realistically willing to offer Ph.D. scientists to attract them, and with higher education administrators to explore programmatic changes they would need to institute to provide Ph.D.s with skills tailored to secondary school teaching. These investigations led to this report which describes the incentives local school districts could use in establishing pilot programs in this area.

DKK 344.00
1

Scientific Evaluation of Biological Opinions on Endangered and Threatened Fishes in the Klamath River Basin - Board On Environmental Studies And

Scientific Evaluation of Biological Opinions on Endangered and Threatened Fishes in the Klamath River Basin - Board On Environmental Studies And

During 2001, a severe drought occurred in the Klamath River Basin. The U.S. Department of the Interior (DOI) determined that the newly issued biological opinions and their RPAs must prevail; thus, water that would have gone to irrigators was directed almost entirely to attempts to maintain minimum lake levels and minimum flows as prescribed in the two RPAs. The severe economic consequences of this change in water management led DOI to request that the National Research Council (NRC) independently review the scientific and technical validity of the government's biological opinions and their RPAs. The NRC Committee on Endangered and Threatened Fishes in the Klamath River Basin was formed in response to this request. The committee was charged with filing an interim report after approximately less than 3 months of study and a final report after about 18 months of study. The interim report, which is summarized here, focuses on the biological assessments of the USBR (2001) and the USFWS and NMFS biological opinions of 2001 regarding the effects of Klamath Project operations on the three listed fish species.

DKK 305.00
1

Exposure of the American Population to Radioactive Fallout from Nuclear Weapons Tests - Committee To Review The Cdc Nci Feasibility Study Of The

Exposure of the American Population to Radioactive Fallout from Nuclear Weapons Tests - Committee To Review The Cdc Nci Feasibility Study Of The

This report is a review of the draft feasibility study that was issued at the request of Congress by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI). Over 500 atmospheric nuclear-weapons tests were conducted at various sites around the world during 1945-1980. As public awareness and concern mounted over the possible health hazards associated with exposure to the fallout from weapons testing, a feasibility study was initiated by CDC and NCI to assess the extent of the hazard. The CDC-NCI study claims that the fallout might have led to approximately 11,000 excess deaths, most caused by thyroid cancer linked to exposure to iodine-131. The committee noted that CDC and NCI used the best available data to estimate exposure and health hazards. The committee does not recommend an expanded study of exposure to radionuclides other than 131I since radiation doses from those radionuclides were much lower than those from 131I. It also recommended that CDC urge Congress to prohibit the destruction of all remaining records relevant to fallout.

DKK 208.00
1

Genetic Status of Atlantic Salmon in Maine - Ocean Studies Board - Bog - National Academies Press - Plusbog.dk

Genetic Status of Atlantic Salmon in Maine - Ocean Studies Board - Bog - National Academies Press - Plusbog.dk

Atlantic salmon in Maine, once abundant but now seriously depleted, were listed as endangered under the federal Endangered Species Act (ESA) in November 2000. The listing covers the wild fish in eight Maine rivers as a single "distinct population segment." The controversy in Maine that accompanied the listing led Congress to request the National Research Council's (NRC's) advice on the science relevant to understanding and reversing the declines in Maine's salmon populations. The charge to the NRC's Committee on Atlantic Salmon in Maine included an interim report focusing on the genetic makeup of Maine Atlantic salmon populations. This is the interim report. Understanding the genetic makeup of Maine's salmon is important for recovery efforts, because the degree to which populations in Maine differ from adjacent populations in Canada and the degree to which populations in different Maine rivers and tributaries differ from each other affect the choice of recovery options that are most likely to be effective. This report focuses only on questions of genetic distinctiveness. The committee's final report will address the broader issues, such as the factors that have caused Maine's salmon populations to decline and the options for helping them to recover.

DKK 305.00
1

Research on Power-Frequency Fields Completed Under the Energy Policy Act of 1992 - National Research Council - Bog - National Academies Press -

Research on Power-Frequency Fields Completed Under the Energy Policy Act of 1992 - National Research Council - Bog - National Academies Press -

Since the 1970s, concerns about health hazards associated with electric and magnetic fields from power lines and from workplace, school, and household use of electricity have led to many studies and continued controversy about whether adverse health effects occur. In the Energy Policy Act of 1992 (Public Law 102-486), Congress authorized a focused national research program to study the possible health effects of exposure to low-intensity, 60-hertz electric and magnetic fields. In response to this legislation and at the request of the Department of Energy (DOE), the National Research Council established a committee under the Board on Radiation Effects Research (BRER) in the Commission on Life Sciences (CLS) to aid in its review of the power-frequency magnetic field research activities completed under the Electric and Magnetic Fields Research and Public Information Dissemination (EMF-RAPID) program that was authorized by the Energy Policy Act. The Research Council's Committee to Review the Research Activities Completed Under the Energy Policy Act of 1992 (EPACT) was asked to review the EMF-RAPID program implemented by DOE and the National Institute of Environmental Health Sciences (NIEHS), and research strategies suggested by other federal and nonfederal groups.

DKK 318.00
1