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Fragile X Syndrome - - Bog - Nova Science Publishers Inc - Plusbog.dk

Fragile X Syndrome - - Bog - Nova Science Publishers Inc - Plusbog.dk

Fragile X syndrome is an inherited disease caused by an excessive length of the FMR protein due to mutations in the FMR1 gene located on the X chromosome. It is commonly described as one of the most common genetic diseases with autism-like behaviours and related developmental disabilities. Beside intellectual delays, behavioural problems, and communication difficulties, mood disorders usually occur. Diagnosis is based on laboratory tests and DNA results. Phenotypes including long and narrow face, large ears, hyper-arched palate, flat feet, ataxia, seizures, anxiety, aggression, and hand-related stereotypic behaviours are frequently observed. Although there is no specific cure, early interventions are highly encouraging, promising, and recommended. Pharmacological treatments may be combined with behavioural and/or cognitive behavioural interventions. Recently, assistive technology-based programs have been implemented. This volume includes seven chapters and addresses the newest advances in the diagnosis and treatment of individuals with Fragile X syndrome. Chapter One encompasses the molecular features and pathological bases of the disease. A comprehensive literature overview was conducted. The role of the FMR protein was emphasized although few studies evaluated its function. Chapter Two deals with the neuropsychiatric symptoms related to the syndrome. A complete conceptual framework was exhaustively detailed. Chapter Three emphasizes the role of pharmacotherapy in the treatment of Fragile X syndrome. A further literature review was carried out. Clinical relevance was outlined. Chapter Four provides the reader with a conceptual analysis. Besides molecular features, brain development was described. Challenging behaviours were included and the importance of the early combined intervention was critically discussed. Chapters Five, Six, and Seven detailed three case reports on the effectiveness and the suitability of assistive technology-based interventions. Specifically, Chapter Five argued for microswitch-cluster technology focused on pursuing the dual simultaneous goal of promoting an adaptive response (i.e., object manipulation) and reducing a challenging behaviour (i.e., hand mouthing). Chapter Six describes a combined microswitch and VOCA program useful to ensure the participant has the choice between independent access to positive stimulation and asking for social interaction. Finally, Chapter Seven includes choice opportunities through an assistive technology-mediated program involving a boy with Fragile X in a functional task. Targeted readers (i.e., caregivers, clinicians, speech therapists, professionals, psychologists, neurologists, parents of children with Fragile X syndrome, teachers) may find interesting and stimulating tips and insights for daily use in clinical research and practice, with the dual objective of diagnosis and treatment.

DKK 718.00
1

X-Ray Optics & Inner-Shell Electronics of Hexagonal BN - Andrey A Pavlychev - Bog - Nova Science Publishers Inc - Plusbog.dk

Protest & Issues Around the Air Force Refueling Tanker - - Bog - Nova Science Publishers Inc - Plusbog.dk

Chitosan-Based Hydrogels for Tissue Engineering Applications - G Luna Barcenas - Bog - Nova Science Publishers Inc - Plusbog.dk

Electrochemical Impedance Spectroscopy - - Bog - Nova Science Publishers Inc - Plusbog.dk

P-Type Transparent Semiconducting Delafossite CuA102+x Thin Film - Kalyan K Chattopadhyay - Bog - Nova Science Publishers Inc - Plusbog.dk

P-Type Transparent Semiconducting Delafossite CuA102+x Thin Film - Kalyan K Chattopadhyay - Bog - Nova Science Publishers Inc - Plusbog.dk

Copper based delafossite transparent semiconducting oxide thin films have recently gained tremendous interest in the field of optoelectronic technology, after the discovery of p-type conductivity in a transparent thin film of copper aluminium oxide (CuAlO2). Most of the well-known and widely used transparent conducting oxide thin films such as ZnO, SnO2, ITO etc. and their doped versions are n-type material, but corresponding p-type transparent conducting oxides were surprisingly missing for a long time until the fabrication of above-mentioned p-CuAlO2 thin film have been published (Nature 1997, 389, 939). This has opened up a new field in opto-electronics device technology, the so-called "Transparent Electronics", where a combination of the two types of transparent conducting oxides in the form of a p-n junction could lead to a ''functional'' window, which transmits visible portion of solar radiation yet generates electricity by the absorption of UV part of it. Non-stoichiometric and doped versions of various new types of p-type transparent conducting oxides with improved optical and electrical properties have been synthesised in the last few years in this direction. Wide range of deposition techniques have been adopted to prepare the films. But fabrication of device quality films by cost-effective deposition techniques such as sputtering, chemical vapour deposition, wet-chemical dip-coating technique etc. are the need of the hour for large-scale production of these films for diverse device applications. Here the authors have discussed the fabrication and opto-electrical characterisation of p-CuAlO2+x thin films by cost-effective and scalable deposition routes such as sputtering and wet-chemical dip-coating technique. The authors have also discussed briefly some of the new developments in the field of p-type transparent conducting oxide thin film technology and an up-to-date and comprehensive description of different Cu-based p-type transparent conducting oxide thin films is presented. Also the origin of p-type conductivity in these transparent oxides has been dealt with considerable attention. Fabrication of all-transparent junctions is also discussed which is most important in the development of ''Transparent Electronics''. Field emission properties of thin films are currently of much interest due to the potential application in field emission displays (FEDs), which are considered to be strong candidate for low-power panel applications. The low-threshold field emission properties of wide-bandgap CuAlO2 thin films have been investigated for its potential applications in FED technology. The films showed considerable low turn-on field. This finding might open up a new direction in the field-emission technology, and a new group of materials (such as, different transparent conducting oxides) might become a promising candidate for low-threshold field emitter. Also, recently, the research on nanostructured materials generates great interest in the scientific community and offers tremendous opportunities in the field of science and technology. Here, the authors have also discussed in brief, the formation of nanocrystalline p-CuAlO2 films, which may open up an extremely important and interesting field of research for the fabrication of all-transparent nano-active devices. This will not only give a new dimension in the field of ''Transparent Electronics'', but new avenues may open up in the nanoparticle research keeping an eye on its tremendous applications in optoelectronics technology.

DKK 534.00
1

Crystal Structure - - Bog - Nova Science Publishers Inc - Plusbog.dk

Digital Tomosynthesis - - Bog - Nova Science Publishers Inc - Plusbog.dk

Polycrystalline Films - - Bog - Nova Science Publishers Inc - Plusbog.dk

Trace Metals - - Bog - Nova Science Publishers Inc - Plusbog.dk

Trace Metals - - Bog - Nova Science Publishers Inc - Plusbog.dk

Many types of urban soils, including tree pit soil, contain elevated concentrations of trace metals as compared to agricultural and natural soils. Chapter One describes how trace metals from vehicular emissions and the degradation of urban infrastructure are carried by runoff into the soil of green infrastructure such as tree pits and grassed boulevards. Chapter Two compiled As concentration data from water wells, sediments, and soils in Araihazar that were collected from the public sources and government agencies. Chapter Three focuses on the investigation of the distribution of Fe plaque in the root epidermis of selected wetland plant species (Phragmites australis, Typha latifolia and Spartina alterniflora) using synchrotron X-ray microfluoresces, X-ray absorption near edge structure and transmission X-ray microscope techniques with (sub)micro-scale resolution. Chapter Four investigates the possibility of temporal and spatial variations of potential ecological risk assessments (PERI) of Cd, Cu, Hg, Pb and Zn in the surface sediments based on four sampling cruises in the Straits of Malacca. Characterization of metals in sediments from the New York/New Jersey Harbor is necessary as part of the basic information needed in work related to dredging and environmental effects and restoration efforts in the region as reported in Chapter Five. Chapter Six discusses the arsenic concentrations in the groundwater of the lowlands of Nepal (the so called Terai).

DKK 1034.00
1

Imines - - Bog - Nova Science Publishers Inc - Plusbog.dk

Two-Dimensional Periodic Nanoscale Patterning of Solid Surfaces by Four-Beam Standing Wave Excimer Laser Lithography - D O Filatov - Bog - Nova

A Classical Description of Variational Quantum Mechanics and Related Models - Fabio Silva Botelho - Bog - Nova Science Publishers Inc - Plusbog.dk

A Classical Description of Variational Quantum Mechanics and Related Models - Fabio Silva Botelho - Bog - Nova Science Publishers Inc - Plusbog.dk

In this text, the author establishes a connection between classical and quantum mechanics through the normal field definition and related wave function concept. Indeed, the author proposes a new energy which includes both classical and quantum mechanics in a unified framework. Concerning such energy, they show that if ℏ≪m, where m denotes the total system mass, then the energy is experienced in a classical mechanics context, whereas if the approximation r(x,t)≈x is assumed, where r(x,t) denotes point-wise the particle classical field of position, and for appropriate m values the standard Schrödinger energies are re-obtained. Among the examples of applications concerning the proposal, the author highlights the hydrogen atom as one example, where both the proton and electron are allowed to move. The consistent result of a proton mass concentration at r = 0 is obtained. The author also develops a procedure to obtain eigenvalues of a positive definite symmetric matrix. The novelty here, concerning previous results in the book entitled Functional Analysis and Applied Optimization in Banach Spaces, are the rigorous proofs presented. Indeed, the results seem to be applicable to more general matrices. However, the author postpones the proof of such general results for future research. In the last chapter, a complete and rigorous existence result for the Ginzburg-Landau system of superconductivity is presented. A duality principle and related optimality conditions are also developed. In the final section, the author presents research concerning numerical results for three-dimensional models in superconductivity.

DKK 820.00
1

Heating Systems - - Bog - Nova Science Publishers Inc - Plusbog.dk

ZnO Nanostructures - - Bog - Nova Science Publishers Inc - Plusbog.dk

An Introduction to Melamine - - Bog - Nova Science Publishers Inc - Plusbog.dk

An Introduction to Melamine - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this compilation, technical and critical aspects concerning confirmatory methods for the analysis of melamine and its analogous, including cyanuric acid, ammeline, and ammelide in foodstuffs are discussed. Moreover, an overview of the concentrations of melamine and related compounds reported in the recent literature for different food items are summarized, as the results from monitoring these compounds in food products indicate their continuing presence in the food chain. Although high level of adulteration has ceased, melamine is still a popular material for pesticides, farm animal feed fillers, fire retardants, anti-wrinkles and mild abrasives. As such, the authors discuss how low-dose contamination of melamine to the environment cannot be ignored. Next, melamine-formaldehyde resin was chosen to form shell material due to its good thermo-mechanical and water-resistant properties. A series of experiments are conducted on changing the emulsifying system and a discussion of the results is provided. Additionally, a sensitive chemical sensor is developed to detect melamine selectively by an electrochemical approach, where ternary mixed metal oxide nanoparticles were prepared through the wet-chemical process. The calcined ZnO/CuO/Co3O4 NPs are investigated by field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, powder X-ray diffraction, ultraviolet visible spectroscopy, and Fourier-transform infrared spectroscopy. The authors evaluate the formation of melamine-derived particles in aqueous and biological matrices using different analytical techniques for studying the bioaccumulation of melamine-cyanurate in tissues, including kidney stones. Lastly, cadmium doped antimony oxide nanostructures are synthesized by a facile wet-chemical method at a low temperature to detect melamine from aqueous solutions. The calcined cadmium doped antimony oxide nanostructures are characterized systematically by FE-SEM, EDS, UV/Vis., FTIR spectroscopy, powder XRD and XPS techniques.

DKK 718.00
1

Cancer Treatment - - Bog - Nova Science Publishers Inc - Plusbog.dk

Medicaid Fee-For-Service Payments - - Bog - Nova Science Publishers Inc - Plusbog.dk

Medicaid Fee-For-Service Payments - - Bog - Nova Science Publishers Inc - Plusbog.dk

On 22 November 2003, the House of Representatives voted 220 to 215 to approve the conference report on H.R. 1, the Medicare Prescription Drug, Improvement, and Modernisation Act of 2003. The Senate, on November 24th, voted 54 to 44 to approve the conference report. The bill was signed by the President in a ceremony on December 8th. The legislation adds a prescription drug benefit to Medicare and replaces the existing Medicare+Choice program with a new Medicare Advantage program that establishes managed care payments based on a system of bids and benchmarks. The bill also contains numerous provisions that would generally increase fee-for-service payments within Medicare''s Part A and Part B program (also known as traditional Medicare), especially for rural health care providers; numerous regulatory and administrative practices will also be modified. This book discusses the fee-for-service (FFS) provisions of the legislation, those affecting Medicaid as well as the Medicare cost containment provisions. It compares the provisions in the bill as enacted with those in the Medicare reform bills that were originally passed by the Senate and the House. The Medicare FFS provisions in the bill are found primarily in Titles GGIII through VIII; some FFS provisions are included in Titles VIII through X as noted. The cost containment provisions are in Title VIII and the Medicaid and other provisions are in Title X.

DKK 316.00
1

Forensic Medicine - - Bog - Nova Science Publishers Inc - Plusbog.dk

Chest Pain - - Bog - Nova Science Publishers Inc - Plusbog.dk

Internet Television Streaming, Copyright Law & the Aereo Supreme Court Decision - - Bog - Nova Science Publishers Inc - Plusbog.dk

Hepatitis B Virus Research Focus - Lihong Ye - Bog - Nova Science Publishers Inc - Plusbog.dk

Hepatitis B Virus Research Focus - Lihong Ye - Bog - Nova Science Publishers Inc - Plusbog.dk

Hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people in the world. The infection of HBV is a leading cause of chronic carriage of the virus and progressive liver diseases, such as hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). HBV consists of a circular, partially double-stranded DNA molecule of 3.2 kb in length, which contains four overlapping reading frames that code for surface proteins (HBsAg), core proteins (HBcAg/HBeAg), the viral polymerase, and the transcriptional transactivator X protein. Chronic hepatitis appears to be due to a suboptimal cellular immune response that destroys some of the infected hepatocytes and does not purge the virus from the remaining infected hepatocytes, thereby permitting the persisting virus to trigger a chronic indolent necroinflammatory liver disease that sets the stage for development of HCC. However, the mechanisms responsible for malignant transformation in chronic HBV infection are not well defined, and both viral and host factors have been implicated in the process. All cases of HCC occur after many years of chronic hepatitis which could, theoretically, provide the mitogenic and mutagenic environment to precipitate random genetic and chromosomal damage, and lead to the development of HCC. Hepatitis B virus X protein (HBx), an important transforming inducer, plays a crucial role in HCC development. HBx has the capability to influence a variety of signal transduction pathways within the cells. Monitoring of the HBV genotypes and antibody to Hepatitis B x antigen (anti-HBx) are significant for predicting early diagnosis of liver cirrhosis and HCC. HBV and Hepatitis C virus or HIV coinfections can accelerate the course of chronic liver disease and facilitate progression to cirrhosis and HCC. As for therapy of liver diseases, five drugs are now FDA-approved for the treatment of HBV, including interferon (IFN), lamivudine, adefovir, entecavir, and peginterferon alfa-2a. Moreover, the prevention for HBV infection is very important. It is likely that the most important outcome of the research on HBV has been the invention, development, and application of the vaccine against HBV. However, at present most investigators focus on basic research rather than practical applications. The HBV research should be focused on animal models and clinical practice. The technology update in HBV research and the multisubject combination may be attached importance to next a few decades. Some molecular approaches, such as antisense, oligonucleotides, ribozymes, RNA interference targeting HBV mRNA, are available in antiviral therapies.

DKK 514.00
1

Contention-Based Collision-Resolution Medium Access Control Algorithms - Jesus Alonso Zarate - Bog - Nova Science Publishers Inc - Plusbog.dk

Foldases Catalyzing the Formation & Isomerization of Disulfide Bonds in Proteins - Natalya K Nagradova - Bog - Nova Science Publishers Inc -

Foldases Catalyzing the Formation & Isomerization of Disulfide Bonds in Proteins - Natalya K Nagradova - Bog - Nova Science Publishers Inc -

One of the rate-limiting steps in the folding pathways of many secretory proteins is the formation of correct disulfide bonds between cysteine residues. In eukaryotes, both disulfide bond formation and isomerisation which shuffles incorrectly formed disulfides are catalysed by protein disulfide isomerase (PDI), whereas in bacteria these two reactions are catalysed by separate enzymes. Both in eukaryotic and prokaryotic cells the oxidation and isomerisation steps proceed exclusively in extracytoplasmic environments (the lumen of the eukaryotic endoplasmic reticulum and the Gram-negative bacterial periplasmic space). The family of foldases under discussion is characterised by a conserved "thioredoxin fold" and a common active site motif: Cys-X-X-Cys. The process of disulfide bond formation relies on thiol-disulfide exchange between oxidised and reduced cysteine pairs in the catalyst and substrate protein. Two separate pathways involved in disulfide bond formation and isomerisation have been characterised both in eukaryotes and in bacteria. In the oxidative pathway, oxidizing equivalents flow from oxygen to a membrane protein (Ero1p in eukaryotes or DsbB in bacteria), and then to a folding protein containing reduced cysteines via PDI (in eukaryotes) or via DsbA (in bacteria). In the isomerisation pathway, DsbC (bacterial protein disulfide isomerase) or PDI (in eukaryotes) interacts with substrate proteins that contain non-native disulfide bonds, allowing these bonds to rearrange to their native pairings. Reducing equivalents which are necessary to maintain DsbC in a reduced form, able to attack misfolded disulfides, are transferred from the cytoplasm with the aid of the cytoplasmic membrane protein DsbD. In eukaryotes, reduced glutathione is the main source of reducing equivalents for PDI. A dual role of PDI as an oxidase and an isomerase is facilitated by its complex domain architecture.

DKK 405.00
1

Porous Structure & Adsorption Behaviours of Chitosan - N V Serebryakova - Bog - Nova Science Publishers Inc - Plusbog.dk