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Protein Targeting and Translocation - - Bog - Princeton University Press - Plusbog.dk

Protein Targeting and Translocation - - Bog - Princeton University Press - Plusbog.dk

Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates.Originally published in 1999.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

DKK 529.00
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Molecular Approaches to Evolution - Jacques Ninio - Bog - Princeton University Press - Plusbog.dk

Molecular Approaches to Evolution - Jacques Ninio - Bog - Princeton University Press - Plusbog.dk

Spin Glasses and Complexity - Charles M. Newman - Bog - Princeton University Press - Plusbog.dk

Robustness and Evolvability in Living Systems - Andreas Wagner - Bog - Princeton University Press - Plusbog.dk

Robustness and Evolvability in Living Systems - Andreas Wagner - Bog - Princeton University Press - Plusbog.dk

All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms'' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.

DKK 573.00
1

Tommaso Campanella and the Transformation of the World - John M. Headley - Bog - Princeton University Press - Plusbog.dk

Tommaso Campanella and the Transformation of the World - John M. Headley - Bog - Princeton University Press - Plusbog.dk

Tommaso Campanella (1568-1639) is one of the most fascinating, if hitherto inaccessible, intellectuals of the Italian Renaissance. His work ranges across many of the intellectual, ecclesiastical, and political concerns of that tumultuous era. John Headley uses Campanella''s life and works to open a window into this complex period. He not only explicates the frequently contradictory texts of a prolific author but also situates Campanella''s writings amidst the larger currents of European thought.For all its obscurely magical and astrolgocial intricacies, Campanella''s entire intellectual endeavor expresses an effort to impose a distinctive order and direction upon the major issues and forces of the age different from that which was shortly to prevail with the new Galilean science and the Leviathan state. In the process of identifying and engaging these issues and imparting in some instances something of his own, he managed to mobilize and deploy many of the salient principles of late medieval and Renaissance culture, often cast in a curiously modern hue and aligned with the new forces of the age. Indeed, modern and antique, new and old juxtapose violently in the person of this reformer who combines an encyclopedic comprehensiveness of intellect with an appalling intensity of will. He is a man who strove to destabilize the regnant forces of what he identified as tyranny, sophistry, and hypocrisy and to shake the world into a new order. In this book, Headley invites readers to look anew at this mercurial figure and at the turbulent times in which he lived.John M. Headley is Professor of History at the University of North Carolina at Chapel Hill. He has authored studies of Luther, Thomas More, the Emperor Charles V, and San Carlo Borromeo.Originally published in 1997.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

DKK 683.00
1

The Hunting Apes - Craig B. Stanford - Bog - Princeton University Press - Plusbog.dk

The Hunting Apes - Craig B. Stanford - Bog - Princeton University Press - Plusbog.dk

What makes humans unique? What makes us the most successful animal species inhabiting the Earth today? Most scientists agree that the key to our success is the unusually large size of our brains. Our large brains gave us our exceptional thinking capacity and led to humans'' other distinctive characteristics, including advanced communication, tool use, and walking on two legs. Or was it the other way around? Did the challenges faced by early humans push the species toward communication, tool use, and walking and, in doing so, drive the evolutionary engine toward a large brain? In this provocative new book, Craig Stanford presents an intriguing alternative to this puzzling question--an alternative grounded in recent, groundbreaking scientific observation. According to Stanford, what made humans unique was meat. Or, rather, the desire for meat, the eating of meat, the hunting of meat, and the sharing of meat. Based on new insights into the behavior of chimps and other great apes, our now extinct human ancestors, and existing hunting and gathering societies, Stanford shows the remarkable role that meat has played in these societies. Perhaps because it provides a highly concentrated source of protein--essential for the development and health of the brain--meat is craved by many primates, including humans. This craving has given meat genuine power--the power to cause males to form hunting parties and organize entire cultures around hunting. And it has given men the power to manipulate and control women in these cultures. Stanford argues that the skills developed and required for successful hunting and especially the sharing of meat spurred the explosion of human brain size over the past 200,000 years. He then turns his attention to the ways meat is shared within primate and human societies to argue that this all-important activity has had profound effects on basic social structures that are still felt today. Sure to spark a lively debate, Stanford''s argument takes the form of an extended essay on human origins. The book''s small format, helpful illustrations, and moderate tone will appeal to all readers interested in those fundamental questions about what makes us human.

DKK 333.00
1