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Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

DKK 332.00
1

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

DKK 1010.00
1

The Importance of Being Urban - David A Gamson - Bog - The University of Chicago Press - Plusbog.dk

The Importance of Being Urban - David A Gamson - Bog - The University of Chicago Press - Plusbog.dk

From the 1890s through World War II, the greatest hopes of American progressive reformers lay not in the government, the markets, or other seats of power but in urban school districts and classrooms. The Importance of Being Urban focuses on four western school systems—in Denver, Oakland, Portland, and Seattle—and their efforts to reconfigure public education in the face of rapid industrialization and the perceived perils [GDA1] of the modern city. In an era of accelerated immigration, shifting economic foundations, and widespread municipal shake-ups, reformers argued that the urban school district could provide the broad blend of social, cultural, and educational services needed to prepare students for twentieth-century life. These school districts were a crucial force not only in orchestrating educational change, but in delivering on the promise of democracy. David A. Gamson’s book provides eye-opening views of the histories of American education, urban politics, and the Progressive Era.

DKK 525.00
1

Yearning for Immortality - Rune Nyord - Bog - The University of Chicago Press - Plusbog.dk

Yearning for Immortality - Rune Nyord - Bog - The University of Chicago Press - Plusbog.dk

How our understanding of the ancient Egyptian afterlife was shaped by Christianity. Many of us are familiar with the ancient Egyptians’ obsession with immortality and the great efforts they made to secure the quality of their afterlife. But, as Rune Nyord shows, even today, our understanding of the Egyptian afterlife has been formulated to a striking extent in Christian terms. Nyord argues that this is no accident, but rather the result of a long history of Europeans systematically retelling the religion of ancient Egypt to fit the framework of Christianity. The idea of ancient Egyptians believing in postmortem judgment with rewards and punishments in the afterlife was developed during the early modern period through biased interpretations that were construed without any detailed knowledge of ancient Egyptian religion, hieroglyphs, and sources. As a growing number of Egyptian images and texts became available through the nineteenth century, these materials tended to be incorporated into existing narratives rather than being used to question them. Against this historical background, Nyord argues that we need to return to the indigenous sources and shake off the Christian expectations that continue to shape scholarly and popular thinking about the ancient Egyptian afterlife.

DKK 1093.00
1

Yearning for Immortality - Rune Nyord - Bog - The University of Chicago Press - Plusbog.dk

Yearning for Immortality - Rune Nyord - Bog - The University of Chicago Press - Plusbog.dk

How our understanding of the ancient Egyptian afterlife was shaped by Christianity. Many of us are familiar with the ancient Egyptians’ obsession with immortality and the great efforts they made to secure the quality of their afterlife. But, as Rune Nyord shows, even today, our understanding of the Egyptian afterlife has been formulated to a striking extent in Christian terms. Nyord argues that this is no accident, but rather the result of a long history of Europeans systematically retelling the religion of ancient Egypt to fit the framework of Christianity. The idea of ancient Egyptians believing in postmortem judgment with rewards and punishments in the afterlife was developed during the early modern period through biased interpretations that were construed without any detailed knowledge of ancient Egyptian religion, hieroglyphs, and sources. As a growing number of Egyptian images and texts became available through the nineteenth century, these materials tended to be incorporated into existing narratives rather than being used to question them. Against this historical background, Nyord argues that we need to return to the indigenous sources and shake off the Christian expectations that continue to shape scholarly and popular thinking about the ancient Egyptian afterlife.

DKK 292.00
1