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Heritable Human Genome Editing - The Royal Society - Bog - National Academies Press - Plusbog.dk

Heritable Human Genome Editing - The Royal Society - Bog - National Academies Press - Plusbog.dk

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight. Table of ContentsFront MatterSummary1 Introduction2 The State of the Science3 Potential Applications of Heritable Human Genome Editing4 A Translational Pathway to Limited and Controlled Clinical Applications of Heritable Human Genome Editing5 National and International Governance of Heritable Human Genome EditingReferencesAppendix A: Information Sources and Methods Appendix B: Commissioner BiographiesAppendix C: GlossaryAppendix D: Acronyms and AbbreviationsAcknowledgment of Reviewers

DKK 71.00
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BRUGT BOG - House of Many Ways - - Bog - Plusbog.dk

BRUGT BOG - House of Many Ways - - Bog - Plusbog.dk

BRUGT BOG - House of Many Ways af Diana Wynne Jones A chaotically magical sequel to Howl’s Moving Castle.Charmain Baker is in over her head. Looking after Great Uncle William''s tiny cottage while he''s ill should have been easy, but Great Uncle William is better known as the Royal Wizard Norland and his house bends space and time. Its single door leads to any number of places – the bedrooms, the kitchen, the caves under the mountains, the past, to name but a few.By opening that door, Charmain is now also looking after an extremely magical stray dog, a muddled young apprentice wizard and a box of the king''s most treasured documents, as well as irritating a clan of small blue creatures.Caught up in an intense royal search, she encounters an intimidating sorceress named Sophie. And where Sophie is, can the Wizard Howl and fire demon Calcifer be far behind?

DKK 70.00
1

Kate, the Duchess of Cambridge Royal Fashions Coloring Book - Eileen Miller - Bog - Dover Publications Inc. - Plusbog.dk

Kate, the Duchess of Cambridge Royal Fashions Coloring Book - Eileen Miller - Bog - Dover Publications Inc. - Plusbog.dk

Thirty pages of beautifully rendered, ready-to-color outfits feature ensembles made famous by the Duchess of Cambridge since her 2011 wedding to Prince William. Costumes include her stunning bridal gown, designed by Sarah Burton, as well as dresses created by Jenny Packham, Emilia Wickstead, the Alexander McQueen fashion house, and others. Captions include designers'' names and color descriptions.

DKK 71.00
1

Tales from the Arabian Nights - Andrew Lang - Bog - Wordsworth Editions Ltd - Plusbog.dk

Tales from the Arabian Nights - Andrew Lang - Bog - Wordsworth Editions Ltd - Plusbog.dk

The beautiful Scheherazade''s royal husband threatens to kill her, so each night she diverts him by weaving wonderful tales of fantastic adventure, leaving each story unfinished so that he spares her life to hear the ending the next night. This is the background to the Arabian Nights. In this selection made by that master of folklore and fairy-tale Andrew Lang, the reader meets Aladdin with his wonderful lamp, the Enchanted Horse, the Princess Badoura, Sinbad the Sailor, and the great Caliph of Bagdad, Haroun-al-Raschid. The stories are beautifully illustrated by H.J. Ford.

DKK 74.00
1

London (Chinese) - Sara Pink - Bog - Batsford - Plusbog.dk

London (Chinese) - Sara Pink - Bog - Batsford - Plusbog.dk

One of the most exhilarating cities in the world, London is steeped in history whilst embracing innovation. Its skyline is a mix of old and new, with the beautiful architectural splendour of St Paul’s Cathedral sitting comfortably alongside the staggering modernity of new high rises. The pomp and ceremony of quintessential British culture remains very much on show, from Changing the Guard to the Lord Mayor’s Show and tea at The Ritz. With world-famous museums, art galleries, theatres, eight royal parks, shops, restaurants and a buzzing nightlife, London has something on offer for everyone. The latest Pitkin guide to London is a fresh, updated edition of our best-seller In and Around London . This guidebook celebrates the most famous icons in our English heritage, as well as introducing the newest architectural additions to the city’s skyline – from museums to The Shard. The book showcases all these top attractions in a fun and accessible manner, offering exciting facts and anecdotes as well as significant historical information. At 44 pages, London is compact enough to fit into a bag or a small piece of hand luggage, but it is still an insightful read. Whether it is an expedition through the museums - back in time to ancient London, following the footsteps of one of the most famous royal families in the world or indulging in the countless eateries, theatres and shopping hubs, this text is the perfect companion to any tourist visiting London.

DKK 58.00
1

London (Japanese) - Sara Pink - Bog - Batsford - Plusbog.dk

London (Japanese) - Sara Pink - Bog - Batsford - Plusbog.dk

One of the most exhilarating cities in the world, London is steeped in history whilst embracing innovation. Its skyline is a mix of old and new, with the beautiful architectural splendour of St Paul’s Cathedral sitting comfortably alongside the staggering modernity of new high rises. The pomp and ceremony of quintessential British culture remains very much on show, from Changing the Guard to the Lord Mayor’s Show and tea at The Ritz. With world-famous museums, art galleries, theatres, eight royal parks, shops, restaurants and a buzzing nightlife, London has something on offer for everyone. The latest Pitkin guide to London is a fresh, updated edition of our best-seller In and Around London . This guidebook celebrates the most famous icons in our English heritage, as well as introducing the newest architectural additions to the city’s skyline – from museums to The Shard. The book showcases all these top attractions in a fun and accessible manner, offering exciting facts and anecdotes as well as significant historical information. At 44 pages, London is compact enough to fit into a bag or a small piece of hand luggage, but it is still an insightful read. Whether it is an expedition through the museums - back in time to ancient London, following the footsteps of one of the most famous royal families in the world or indulging in the countless eateries, theatres and shopping hubs, this text is the perfect companion to any tourist visiting London.

DKK 58.00
1

London (German) - Sara Pink - Bog - Batsford - Plusbog.dk

London (German) - Sara Pink - Bog - Batsford - Plusbog.dk

One of the most exhilarating cities in the world, London is steeped in history whilst embracing innovation. Its skyline is a mix of old and new, with the beautiful architectural splendour of St Paul’s Cathedral sitting comfortably alongside the staggering modernity of new high rises. The pomp and ceremony of quintessential British culture remains very much on show, from Changing the Guard to the Lord Mayor’s Show and tea at The Ritz. With world-famous museums, art galleries, theatres, eight royal parks, shops, restaurants and a buzzing nightlife, London has something on offer for everyone. The latest Pitkin guide to London is a fresh, updated edition of our best-seller In and Around London . This guidebook celebrates the most famous icons in our English heritage, as well as introducing the newest architectural additions to the city’s skyline – from museums to The Shard. The book showcases all these top attractions in a fun and accessible manner, offering exciting facts and anecdotes as well as significant historical information. At 44 pages, London is compact enough to fit into a bag or a small piece of hand luggage, but it is still an insightful read. Whether it is an expedition through the museums - back in time to ancient London, following the footsteps of one of the most famous royal families in the world or indulging in the countless eateries, theatres and shopping hubs, this text is the perfect companion to any tourist visiting London.

DKK 58.00
1

London (Italian) - Sara Pink - Bog - Batsford - Plusbog.dk

London (Italian) - Sara Pink - Bog - Batsford - Plusbog.dk

One of the most exhilarating cities in the world, London is steeped in history whilst embracing innovation. Its skyline is a mix of old and new, with the beautiful architectural splendour of St Paul’s Cathedral sitting comfortably alongside the staggering modernity of new high rises. The pomp and ceremony of quintessential British culture remains very much on show, from Changing the Guard to the Lord Mayor’s Show and tea at The Ritz. With world-famous museums, art galleries, theatres, eight royal parks, shops, restaurants and a buzzing nightlife, London has something on offer for everyone. The latest Pitkin guide to London is a fresh, updated edition of our best-seller In and Around London . This guidebook celebrates the most famous icons in our English heritage, as well as introducing the newest architectural additions to the city’s skyline – from museums to The Shard. The book showcases all these top attractions in a fun and accessible manner, offering exciting facts and anecdotes as well as significant historical information. At 44 pages, London is compact enough to fit into a bag or a small piece of hand luggage, but it is still an insightful read. Whether it is an expedition through the museums - back in time to ancient London, following the footsteps of one of the most famous royal families in the world or indulging in the countless eateries, theatres and shopping hubs, this text is the perfect companion to any tourist visiting London.

DKK 58.00
1

London (French) - Sara Pink - Bog - Batsford - Plusbog.dk

London (French) - Sara Pink - Bog - Batsford - Plusbog.dk

One of the most exhilarating cities in the world, London is steeped in history whilst embracing innovation. Its skyline is a mix of old and new, with the beautiful architectural splendour of St Paul’s Cathedral sitting comfortably alongside the staggering modernity of new high rises. The pomp and ceremony of quintessential British culture remains very much on show, from Changing the Guard to the Lord Mayor’s Show and tea at The Ritz. With world-famous museums, art galleries, theatres, eight royal parks, shops, restaurants and a buzzing nightlife, London has something on offer for everyone. The latest Pitkin guide to London is a fresh, updated edition of our best-seller In and Around London . This guidebook celebrates the most famous icons in our English heritage, as well as introducing the newest architectural additions to the city’s skyline – from museums to The Shard. The book showcases all these top attractions in a fun and accessible manner, offering exciting facts and anecdotes as well as significant historical information. At 44 pages, London is compact enough to fit into a bag or a small piece of hand luggage, but it is still an insightful read. Whether it is an expedition through the museums - back in time to ancient London, following the footsteps of one of the most famous royal families in the world or indulging in the countless eateries, theatres and shopping hubs, this text is the perfect companion to any tourist visiting London.

DKK 58.00
1

Saga of the Jack of Spades, The: Volume 1 - Chase Kantor - Bog - Renegade Arts Canmore Ltd - Plusbog.dk

Saga of the Jack of Spades, The: Volume 1 - Chase Kantor - Bog - Renegade Arts Canmore Ltd - Plusbog.dk

For centuries, The Four Kingdoms, the Hearts, Clubs, Diamonds, and Spades, waged war upon each other. To stem the bloodshed, the Four of a Kind, an order of wise and holy men, were entrusted to keep the peace at any cost. But the wheels of war are turning once more. All eyes are on Jack, the young Prince of Spades, and he is eager to prove to the royal court and himself that he''s worthy of the crown. It is up to Jack to round up the enemies of the Spade Crown and deliver the King''s justice. As the King''s enemies grow more desperate, their murderous aim turns to Prince Jack.

DKK 74.00
1

George VI and Elizabeth - Sally Bedell Smith - Bog - Penguin Books Ltd - Plusbog.dk

George VI and Elizabeth - Sally Bedell Smith - Bog - Penguin Books Ltd - Plusbog.dk

A revelatory account of how King George VI and Queen Elizabeth''s loving marriage saved the monarchy during World War II, and how they raised their daughter to become Queen Elizabeth II, based on exclusive access to the Royal Archives From the bestselling author of Elizabeth the Queen and Prince Charles ___________Granted special access by Queen Elizabeth II to her parents'' letters and diaries and to the papers of their close friends and family, Sally Bedell Smith brings the love story of this iconic royal couple to vibrant life.This deeply researched and revealing book shows how a loving and devoted marriage helped the King and Queen meet the challenges of World War II, lead a nation, solidify the public''s faith in the monarchy, and raise their daughters, Princess Elizabeth and Princess Margaret.From the abdication of King Edward VIII in 1936, to King George VI''s fierce leadership as we navigated World War II, this is the definitive account of not only the man behind the throne, but the woman - and the marriage - that made his reign so successful. Forming relationships with Winston Churchill and Franklin Roosevelt, and inspiring the British people with their courage and compassion during the blitz, George VI and Elizabeth also raised their daughter Princess Elizabeth. It was from her parents'' leadership that she spent her childhood learning, watching, and preparing to become the future queen. In this deeply personal account, Sally Bedell Smith gives us an inside view of the lives, struggles, hopes, and triumphs of King George VI and Elizabeth during a dramatic time in history.

DKK 46.00
1

BRUGT BOG - The Memoirs of Sherlock Holmes - Sir Arthur Conan Doyle - Bog - Pan Macmillan - Plusbog.dk

BRUGT BOG - The Memoirs of Sherlock Holmes - Sir Arthur Conan Doyle - Bog - Pan Macmillan - Plusbog.dk

BRUGT BOG Sherlock Holmes is back on the case in this collection of sparkling short stories, in which we learn about Holmes' early days as a sleuth, encounter a seemingly murderous widow, and meet the great detective's brother, Mycroft, for the first time. And, in 'The Final Problem', Holmes comes face-to-face with his nemesis, Professor Moriarty, in a battle of wits that could kill them both.Part of the Macmillan Collector’s Library; a series of stunning, clothbound, pocket-sized classics with gold foiled edges and ribbon markers. These beautiful books make perfect gifts or a treat for any book lover. This edition features an afterword by David Stuart Davies - a Fellow of the Royal Literary Fund and an authority on Sherlock Holmes.

DKK 62.00
1

BRUGT BOG - Queens of Jerusalem - Katherine Pangonis - Bog - Orion Publishing Co - Plusbog.dk

BRUGT BOG - Queens of Jerusalem - Katherine Pangonis - Bog - Orion Publishing Co - Plusbog.dk

BRUGT BOG In 1187 Saladin''s armies besieged the holy city of Jerusalem. He had previously annihilated Jerusalem''s army at the battle of Hattin, and behind the city''s high walls a last-ditch defence was being led by an unlikely trio - including Sibylla, Queen of Jerusalem. They could not resist Saladin, but, if they were lucky, they could negotiate terms that would save the lives of the city''s inhabitants.Queen Sibylla was the last of a line of formidable female rulers in the Crusader States of Outremer. Yet for all the many books written about the Crusades, one aspect is conspicuously absent: the stories of women. Queens and princesses tend to be presented as passive transmitters of land and royal blood. In reality, women ruled, conducted diplomatic negotiations, made military decisions, forged alliances, rebelled, and undertook architectural projects. Sibylla''s grandmother Queen Melisende was the first queen to seize real political agency in Jerusalem and rule in her own right. She outmanoeuvred both her husband and son to seize real power in her kingdom, and was a force to be reckoned with in the politics of the medieval Middle East. The lives of her Armenian mother, her three sisters, and their daughters and granddaughters were no less intriguing.The lives of this trailblazing dynasty of royal women, and the crusading Queen Eleanor of Aquitaine, are the focus of Katherine Pangonis''s debut book. In QUEENS OF JERUSALEM she explores the role women played in the governing of the Middle East during periods of intense instability, and how they persevered to rule and seize greater power for themselves when the opportunity presented itself.

DKK 60.00
1

Crooked Dances - Robin French - Bog - Bloomsbury Publishing PLC - Plusbog.dk

Crooked Dances - Robin French - Bog - Bloomsbury Publishing PLC - Plusbog.dk

You''ve heard of magic hour right? We''re in it. right now. Journalist Katy is desperate for her big break, and an interview in Paris with world famous concert pianist Silvia de Zingaro looks like just her chance.But the odds are against her. After a disastrous interview, Katy feels certain there''s a bigger story there than meets the eye. She hunts for clues, finding Silvia has a collection of mystical books and an apparent fixation with composer Erik Satie. Just as Katy''s hope begins to fade, a mysterious night-time encounter with the pianist may well give her the scoop she''s looking for…This compelling new play examines music, time and attention in our modern digital age.This edition was published to coincide with the world premiere at the Royal Shakespeare Company in Stratford Upon Avon in June 2019.

DKK 66.00
1

The High Flyer - Elizabeth Darrell - Bog - Canongate Books - Plusbog.dk

The High Flyer - Elizabeth Darrell - Bog - Canongate Books - Plusbog.dk

Twelve years after World War I, former Flight Sergeant Ben Norton must discover the truth behind his wartime colleague''s death. 1930. The Lance family, major shareholders in Marshfield Aviation, watch in horror as their prototype fighter fails to pull out of a dive during a display before government and military VIPs. At the pilot''s funeral, a man introduces himself to the widow as Ben Norton, a close friend of her husband during war service with the Royal Flying Corps. Ben becomes Marshfield''s new Test Pilot, determined to refute worldwide press claims of a faulty aircraft design. Convinced that deliberate sabotage was behind the crash, the young flyer vows to uncover whoever was responsible. But who is Ben Norton? And why is it that the man he claims to have been his close wartime colleague had not once mentioned Ben to his wife during eight years of marriage?

DKK 68.00
1