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Computational Protein-Protein Interactions - - Bog - Taylor & Francis Ltd - Plusbog.dk

Computational Protein-Protein Interactions - - Bog - Taylor & Francis Ltd - Plusbog.dk

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. Explores Computational Approaches to Understanding Protein-Protein Interactions Outlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats. Addresses the Next Big Problem in Molecular Biology While it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.

DKK 745.00
1

Medicinal Protein Engineering - - Bog - Taylor & Francis Ltd - Plusbog.dk

Medicinal Protein Engineering - - Bog - Taylor & Francis Ltd - Plusbog.dk

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems. Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins. Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking

DKK 625.00
1

Protein Engineering and Design - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Engineering and Design - - Bog - Taylor & Francis Ltd - Plusbog.dk

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science. Experimental Protein Engineering The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering. Computational Protein Design The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.

DKK 496.00
1

Protein Structure - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Structure - - Bog - Taylor & Francis Ltd - Plusbog.dk

This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.

DKK 656.00
1

Protein Arrays, Biochips and Proteomics - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Arrays, Biochips and Proteomics - - Bog - Taylor & Francis Ltd - Plusbog.dk

From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.

DKK 656.00
1

Protein Discovery Technologies - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Discovery Technologies - - Bog - Taylor & Francis Ltd - Plusbog.dk

A True Insider’s Guide to the Field – Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors’ past scientific achievements. Incorporates Short, Personal Discovery Vignettes Rather than an exhaustive field analysis, this globally pertinent resource presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control. This readily accessible resource discusses an array of interesting topics, including: - - Tumor necrosis factors - The origin of interferon as an angiogenesis inhibitor - In vivo combinatorial mapping of vascular zip codes - Extracellular matrix degradome as regulators of angiogenesis and tumor growth - A matricellular protein prototype - The use of RING finger proteins as E3 Ubiquitin Ligases - Whereas most books tend to be more specialized, this book contains a broad view of the protein discoveries in many different fields, making Protein Discovery Technologies a valuable reference for today’s researchers, both the new and more seasoned, who are seeking a newfound perspective or a deeper understanding of this exciting field.

DKK 643.00
1

Protein Engineering For Industrial Biotechnology - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Engineering For Industrial Biotechnology - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein engineering has proved to be one of the more fruitful technological approaches in biotechnology, being both very powerful and able to generate valuable intellectual property. This book aims to present examples in which the application of protein engineering has successfully solved problems arising in industrial biotechnology. There is a section on its use to enhance purification of recombinant proteins. The use of protein engineering to modify the activity or the stability of industrial enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to degrade recalcitrant compounds is extensively covered. It is shown how areas as diverse as agrofood technology, fine chemistry, detergents, bioremediation and biosensors receive significant contributions from protein and solvent engineering. The application of protein engineering to health care is also covered, from the development of new vaccines to new potential therapeutic proteins. A specific notation is given to protein engineering in the development of target molecules for drug discovery. International in scope, the many contributions are drawn from academia and industry. The text should be of interest to students and researchers in industrial biotechnology as well as to everybody interested in basic research in protein structure, molecular genetics, bio-organic chemistry, biochemistry, agrobiotechnology, pharmaceutical sciences and medicine.

DKK 643.00
1

Genetically Engineered Protein Nanomaterials - Urartu Ozgur Safak Seker - Bog - Springer Verlag, Singapore - Plusbog.dk

Genetically Engineered Protein Nanomaterials - Urartu Ozgur Safak Seker - Bog - Springer Verlag, Singapore - Plusbog.dk

This book highlights the latest advances in nanosized polymerized protein structures that are involved in cellular events. These structures have inspired the creation of innovative protein nanomaterials using genetic and protein engineering strategies, some of which are addressed in this book. These structures can be classified into three major groups: Cage proteins, viral capsid proteins and amyloid proteins.

DKK 418.00
1

Single Cell Protein Production from Lignocellulosic Biomass - Dr. Pratima Bajpai - Bog - Springer Verlag, Singapore - Plusbog.dk

Single Cell Protein Production from Lignocellulosic Biomass - Dr. Pratima Bajpai - Bog - Springer Verlag, Singapore - Plusbog.dk

This book focuses on bioconversion of lignocellulosic residues into single-cell protein, which offers an alternative to conventional proteins (such as soybean meal, egg protein or meat protein in animal feed) that is not affected by the climate. It provides an overview of the general uses of lignocellulosic residues and their bioconversion into single-cell protein using microorganisms, as well as the recovery of the valuable by-products. It also explores the benefits and potential drawbacks of single-cell protein, with an emphasis on the economic advantages of such processes. Given its multidisciplinary scope, the book represents a valuable resource for academics and industry practitioners interested in the production of single-cell protein from lignocellulosic residues.

DKK 426.00
1

Protein Expression - - Bog - Oxford University Press - Plusbog.dk

Protein Expression - - Bog - Oxford University Press - Plusbog.dk

Protein Expression: A Practical Approach and its companion volume Post-translational Modification: A Practical Approach complete the mini-series of Practical Approach books covering the synthesis and subsequent processing of proteins. Protein Expression: A Practical Approach details the expression of cloned DNA or RNA templates in all the major in vivo and in vitro systems. The in vivo systems covered are cultured mammalian cells, the yeasts Saccharomyces cerevisiae and Pichia pastoris, baculovirus, Xenopus oocytes, and prokaryotic cells. Cell-free systems of both eukarytotes and prokaryotes are described, including the prokaryotic systems that offer copuled transcription- translation. There is also a chapter on monitoring protein expression. The post- translational fate of proteins is covered in Post-Translational Processing: A Practical Approach.

DKK 528.00
1

Protein Purification Techniques - - Bog - Oxford University Press - Plusbog.dk

Protein Purification Techniques - - Bog - Oxford University Press - Plusbog.dk

Proteins are an integral part of molecular and cellular structure and function and are probably the most purified type of biological molecule. In order to elucidate the structure and function of any protein it is first necessary to purify it. Protein purification techniques have evolved over the past ten years with improvements in equipment control, automation, and separation materials, and the introduction of new techniques such as affinity membranes and expanded beds. These developments have reduced the workload involved in protein purification, but there is still a need to consider how unit operations linked together to form a purification strategy, which can be scaled up if necessary. The two Practical Approach books on protein purification have therefore been thoroughly updated and rewritten where necessary. The core of both books is the provision of detailed practical guidelines aimed particularly at laboratory scale purification. Information on scale-up considerations is given where appropriate. The books are not comprehensive but do cover the major laboratory techniques and common sources of protein. Protein Purification Techniques focuses on unit operations and analytical techniques. It starts with an overview of purification strategy and then covers initial extraction and clarification techniques. The rest of the book concentrates on different purification methods with the emphasis being on chromatography. The final chapter considers general scale-up considerations. Protein Purification Applications describes purification strategies from common sources: mammalian cell culture, microbial cell culture, milk, animal tissue, and plant tissue. It also includes chapters on purification of inclusion bodies, fusion proteins, and purification for crystallography. A purification strategy that can produce a highly pure single protein from a crude mixture of proteins, carbohydrates, lipids, and cell debris to is a work of art to be admired. These books (available individually or as a set)are designed to give the laboratory worker the information needed to undertake the challenge of designing such a strategy.

DKK 616.00
1

Fibroblast Activation Protein Imaging, An Issue of PET Clinics - - Bog - Elsevier - Health Sciences Division - Plusbog.dk

Fibroblast Activation Protein Imaging, An Issue of PET Clinics - - Bog - Elsevier - Health Sciences Division - Plusbog.dk

In this issue, guest editors bring their considerable expertise to this important topic. Contains 16 practice-oriented topics including fibroblast activation protein inhibitor (FAPI) PET imaging in pancreatic cancer; fibroblast activation protein inhibitor (FAPI) PET imaging in colorectal cancer; fibroblast activation protein inhibitor (FAPI) cardiac imaging; fibroblast activation protein inhibitor (FAPI) PET/CT in gastric cancer; and more. Provides in-depth clinical reviews on fibroblast activation protein imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

DKK 607.00
1

G Protein-Coupled Receptors - Jing Wang - Bog - Springer Verlag, Singapore - Plusbog.dk

G Protein-Coupled Receptors - Jing Wang - Bog - Springer Verlag, Singapore - Plusbog.dk

This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.

DKK 434.00
1

Protein Purification - Philip (nottingham Trent University Bonner - Bog - Taylor & Francis Inc - Plusbog.dk

Protein Purification - Philip (nottingham Trent University Bonner - Bog - Taylor & Francis Inc - Plusbog.dk

This second edition of Protein Purification provides a guide to the major chromatographic techniques, including non-affinity absorption techniques, affinity procedures, non-absorption techniques and methods for monitoring protein purity. The new edition of the book has been organized to encourage incremental learning about the topic, starting with the properties of water, progressing through the characteristics of amino acids and proteins which relate to the purification process. There is an overview of protein strategy and equipment, followed by discussions and examples of each technique and their applications. The basic theory and simple explanations given in Protein Purification make it an ideal handbook for final year undergraduates, and postgraduates, who are conducting research projects. It will also be a useful guide to more experienced researchers who need a good overview of the techniques and products used in protein purification. Key Features * Guide to the major techniques used in protein purification * Includes flowcharts to help the reader slect the best purification strategy * Contains step-by-step protocols that guide the reader through each technique and its use * Includes exercises and solutions

DKK 717.00
1

Protein Bioseparation Using Ultrafiltration: Theory, Applications And New Developments - Raja Ghosh - Bog - Imperial College Press - Plusbog.dk

Protein Bioseparation Using Ultrafiltration: Theory, Applications And New Developments - Raja Ghosh - Bog - Imperial College Press - Plusbog.dk

Ultrafiltration is a pressure-driven, membrane-based separation process, which is used for a broad variety of applications, ranging from the processing of biological macromolecules to wastewater treatment. It has significant advantages over competing separation technologies. Food and biotechnological applications account for nearly 40% of the current total usage of ultrafiltration membranes. Protein bioseparation is an important component of this application segment. Ultrafiltration is used for protein concentration, desalting, clarification and fractionation (i.e. protein-protein separation). Concentration, desalting and clarification are technologically less demanding and have been in used in the bioprocess industry for some time. Protein fractionation, on the other hand, is a challenging proposition and is definitely a more recent development. This book focuses primarily on protein fractionation.

DKK 767.00
1

A Practical Guide to Protein Engineering - Tuck Seng Wong - Bog - Springer Nature Switzerland AG - Plusbog.dk

A Practical Guide to Protein Engineering - Tuck Seng Wong - Bog - Springer Nature Switzerland AG - Plusbog.dk

This textbook introduces readers in an accessible and engaging way to the nuts and bolts of protein expression and engineering. Various case studies illustrate each step from the early sequence searches in online databases over plasmid design and molecular cloning techniques to protein purification and characterization. Furthermore, readers are provided with practical tips to successfully pursue a career as a protein engineer. With protein engineering being a fundamental technique in almost all molecular biology labs, the book targets advanced undergraduates and graduate students working in molecular biology, biotechnology and related scientific fields.

DKK 646.00
1

Alternative Protein Sources in Aquaculture Diets - - Bog - Taylor & Francis Ltd - Plusbog.dk

Alternative Protein Sources in Aquaculture Diets - - Bog - Taylor & Francis Ltd - Plusbog.dk

A unique resource that describes the ingredients included in an aquaculture diet, species profiles, processing methods, impacts to environment and industry, and more. Aquaculture is and will remain a major food producing sector in the future. To become more efficient and successful in the aquaculture industry, operations need to provide good nutrition. Alternative Protein Sources in Aquaculture Diets is a unique source describing the ingredients included in fish and crustacean diets, their nutrient compositions, species profiles, suitability for species, processing methods, and impacts of alternative ingredients on the environment and to the aquaculture industry. World-renowned nutritionists and feed technologists explore practical ways for the aquaculture industry to expand and remain competitive, and discuss ways to develop less expensive alternative sources or protein. Diet costs take up a huge chunk of operating expenditures, with fish meal being one of the most expensive ingredients in the aquaculture diet. Alternative Protein Sources in Aquaculture Diets provides detailed knowledge on the use of alternative plant and animal protein sources, offering opportunities to either partially or completely replace fish meal. This comprehensive, up-to-date text discusses the most widely used ingredients as well as various previously under-utilized ingredients which could be of significant potential in the future. The book is extensively referenced and includes numerous helpful tables to clearly present data. Topics discussed in Alternative Protein Sources in Aquaculture Diets (for finfish and crustacean species) include: • farmed fish diet requirements • reduction of waste through diet formulation • poultry by-product meal • meat packing by-products • soybean protein foodstuffs • cottonseed meal • lupins • unconventional plant protein supplements.

DKK 643.00
1

Protein Misfolding in Neurodegenerative Diseases - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Misfolding in Neurodegenerative Diseases - - Bog - Taylor & Francis Ltd - Plusbog.dk

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

DKK 643.00
1

The Diversified Benefits of Whey Protein - - Bog - Nova Science Publishers Inc - Plusbog.dk

The Diversified Benefits of Whey Protein - - Bog - Nova Science Publishers Inc - Plusbog.dk

The Diversified Benefits of Whey Protein provides an overview of the main benefits of using whey proteins as targeted delivery systems in encapsulation processes, considering prerequisite steps such as binding mechanisms. The authors discuss how, according to current scientific knowledge, whey protein can reduce blood pressure and the risk of hypertension due to the presence of individual bioactive peptides formed after hydrolysis. The effect of whey protein on appetite/satiety of healthy overweight and obese individuals is investigated through a questionnaire wherein subjects were asked to indicate their feelings on the taste, aroma and edibility of a test beverage.

DKK 624.00
1

The Fluorescent Protein Revolution - - Bog - Taylor & Francis Ltd - Plusbog.dk

The Fluorescent Protein Revolution - - Bog - Taylor & Francis Ltd - Plusbog.dk

Advances in fluorescent proteins, live-cell imaging, and superresolution instrumentation have ushered in a new era of investigations in cell biology, medicine, and physiology. From the identification of the green fluorescent protein in the jellyfish Aequorea victoria to the engineering of novel fluorescent proteins, The Fluorescent Protein Revolution explores the history, properties, and applications of these important probes. The book first traces the history of fluorescent proteins and the revolution they enabled in cellular imaging. It then discusses fluorescent proteins with novel photophysical properties. The book also covers several cutting-edge imaging applications. These include superresolution microscopy of cellular fine structures, FRET microscopy to visualize protein interactions and cell-signaling activities inside living cells, photobleaching and photoactivation techniques to visualize protein behaviors, techniques that exploit plant and algal photoreceptors to enable light-regulated control of enzymatic activities, and the noninvasive imaging of tumor–host interactions in living animals. In color throughout, this book presents the fundamental principles and latest advances in the field, including the associated development of imaging techniques that exploit fluorescent proteins. It is accessible to a broad audience, from optical imaging experts to novices needing an introduction to the field.

DKK 643.00
1

Methods for Investigation of Amino Acid and Protein Metabolism - - Bog - Taylor & Francis Ltd - Plusbog.dk

Methods for Investigation of Amino Acid and Protein Metabolism - - Bog - Taylor & Francis Ltd - Plusbog.dk

Containing all the new as well as classical methodologies used in the investigation of amino acid and protein metabolism in human and animal models, this book is needed because of the dramatic increase in research in this field. There is no other book currently on the market that covers these methods of investigation. Methods for Investigation of Amino Acid and Protein Metabolism explores areas such as amino acid transfer across tissue membranes, past and new applications using stable isotopes, protein synthesis in organs and tissues, and more. Because of the importance of research methods in the field of amino acid and protein nutrition and metabolism, this book facilitates the reader''s integration of the concepts involved in these investigative research methods and their corollaries. In addition to helping any nutrition investigator design and conduct appropriate research protocols in this area of nutrition, this book assists students who are planning to investigate amino acid and protein metabolism in humans or laboratory animals.

DKK 643.00
1