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Computational Protein-Protein Interactions - - Bog - Taylor & Francis Ltd - Plusbog.dk

Computational Protein-Protein Interactions - - Bog - Taylor & Francis Ltd - Plusbog.dk

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. Explores Computational Approaches to Understanding Protein-Protein Interactions Outlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats. Addresses the Next Big Problem in Molecular Biology While it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.

DKK 745.00
1

Protein Structure - - Bog - Oxford University Press - Plusbog.dk

Protein Structure - - Bog - Oxford University Press - Plusbog.dk

New and updated, this second edition of Protein Structure presents electrophoretic, chromatographic, and spectrophotometric techniques as well as including new chapters on the relatively sophisticated methods of mass spectrometry and ultracentrifugation. The emphasis is not on the technical aspects of the instruments, but more on the practical aspects of sample preparation and the possibilities of experimental strategy and design. The companion volume to this book, Protein Function: A Practical Approach, details comparable simple techniques for characterizing protein function. Topics in this second volume include: protein molecular weight determination by SDS-PAGE; protein analysis by mass spectrometry; immunological detection of proteins of known sequence; identification of common post-translational modifications; peptide mapping; counting integral numbers of residues by chemical modification; disulfide bonds between cysteine residues; analysis of protein conformation by gel electrophoresis; hydrodynamic properties of proteins; determining the molar absorbance coefficient of a protein; optical spectroscopy to characterize protein conformation and conformational changes; measuring the conformational stability of a protein; imunochemical analysis of protein conformation; stabilization of protein structure by solvents. Protein Structure: A Practical Approach will prove invaluable to all researchers, from PhD students to experienced group leaders.

DKK 829.00
1

Medicinal Protein Engineering - - Bog - Taylor & Francis Ltd - Plusbog.dk

Medicinal Protein Engineering - - Bog - Taylor & Francis Ltd - Plusbog.dk

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems. Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins. Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking

DKK 625.00
1

Protein Engineering and Design - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Engineering and Design - - Bog - Taylor & Francis Ltd - Plusbog.dk

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science. Experimental Protein Engineering The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering. Computational Protein Design The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.

DKK 496.00
1

Protein Structure - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Structure - - Bog - Taylor & Francis Ltd - Plusbog.dk

This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.

DKK 656.00
1

Protein Arrays, Biochips and Proteomics - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Arrays, Biochips and Proteomics - - Bog - Taylor & Francis Ltd - Plusbog.dk

From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.

DKK 656.00
1

Protein Folding - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Protein Folding - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides comprehensive protocols on experimental and computational methods that are used to study probe protein folding reactions and mechanisms. Chapters divided into five parts detail protein engineering, protein chemistry, experimental approaches to investigate the thermodynamics and kinetics of protein folding transitions, probe protein folding at the single molecule, analysis and interpretation of computer simulations, procedures and tools for the prediction of protein folding properties. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Folding: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

DKK 799.00
1

High Protein Vegan - Rose Wyles - Bog - Octopus Publishing Group - Plusbog.dk

High Protein Vegan - Rose Wyles - Bog - Octopus Publishing Group - Plusbog.dk

Over 100 protein-packed, plant-based recipes Give your body the boost it needs with over 100 high-protein vegan recipes With a plant-based diet, it is essential to ensure you are consuming enough protein. Inside this cookbook, you will find over 100 tasty and healthy high-protein meals for every time of day. Qualified plant-based nutritionist Rose Wyles offers expert advice on the ideal protein intake and how to effortlessly boost the protein count of vegan dishes. Complete with calorie-counted recipes, full nutritional breakdowns and meal planners, High Protein Vegan will help you fuel your body with nourishing, nutritious recipes. CONTENTS INCLUDE: Breakfast Chickpea & spinach omelette; Vegan sausage & sweet potato hash; Toffee & banana pancakes Lunch Marinated tofu with vegetables; Chilli & courgette penne; Quick quesadillas Snack Cheat's pepper pizza; Griddled Greek-style sandwiches; Double-berry muffins Dinner Vegan lentil bolognese; Spicy chickpea curry; Vegan shepherd's pie Dessert Chili chocolate chip muffins; Peanut butter cookies; Warm pecan caramel cupcakes

DKK 168.00
1

Prioritizing Protein - Mellissa Sevigny - Bog - Penguin Random House Group - Plusbog.dk

Prioritizing Protein - Mellissa Sevigny - Bog - Penguin Random House Group - Plusbog.dk

In Prioritizing Protein, Melissa Sevigny delves into the pivotal role that protein plays in our overall health and well-being. You will learn why protein is an essential building block to good health and find practical ways to incorporate more of it into your meals to support your health goals. Sevigny begins by detailing the power of protein in our diet, breaking down its essential functions in the body and dispelling common misconceptions. You will learn how our bodies use protein, the benefits, any potential drawbacks, and who specifically can benefit most from leveling up their protein intake. Prioritizing Protein will answer all of your questions, including what the current recommended daily allowance is for each age group, how needs differ between men and women, how to adjust your protein intake based on your activity level and fitness goals, and how to calculate your personal needs. With 150 recipes and weekly and monthly meal plans, a breakdown of the types of protein and their benefits, a protein guide specifically for vegetarians, and a guide to meal prepping, along with tips for sourcing quality protein, stocking your pantry, and shopping on a budget, this one-stop-shop will help you gain the knowledge and confidence you need to start making impactful changes to your health today. Prioritizing Protein features recipes and ingredients for individual diet plans and is formatted with recipe keys to help you navigate what works best for your unique needs. If you are looking for gluten-free, keto, vegetarian, or nut-, egg-, or dairy-free recipes, or you want to know what to eat pre- and post-workout, or you need meals that you can make in 30 minutes or less, Sevigny has you covered!

DKK 367.00
1

Protein Discovery Technologies - - Bog - Taylor & Francis Ltd - Plusbog.dk

Protein Discovery Technologies - - Bog - Taylor & Francis Ltd - Plusbog.dk

A True Insider’s Guide to the Field – Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors’ past scientific achievements. Incorporates Short, Personal Discovery Vignettes Rather than an exhaustive field analysis, this globally pertinent resource presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control. This readily accessible resource discusses an array of interesting topics, including: - - Tumor necrosis factors - The origin of interferon as an angiogenesis inhibitor - In vivo combinatorial mapping of vascular zip codes - Extracellular matrix degradome as regulators of angiogenesis and tumor growth - A matricellular protein prototype - The use of RING finger proteins as E3 Ubiquitin Ligases - Whereas most books tend to be more specialized, this book contains a broad view of the protein discoveries in many different fields, making Protein Discovery Technologies a valuable reference for today’s researchers, both the new and more seasoned, who are seeking a newfound perspective or a deeper understanding of this exciting field.

DKK 643.00
1

Macromolecular Protein Complexes IV - - Bog - Springer International Publishing AG - Plusbog.dk

Macromolecular Protein Complexes IV - - Bog - Springer International Publishing AG - Plusbog.dk

This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, the result of an impressive integration of structural data from X-ray crystallography and cryo-electron microscopy. The functional aspects of protein-protein interactions are also given a high priority.

DKK 816.00
1