Protein Purification: Principles and Trends - Iconcept Press

Chapter 1 uses SILAC and TMT quantitative MS methods to identify novel target proteins modulated in the erlotinib (EGFR TKI) resistant lung cancer cells. The use of multiplex quantitative proteomic strategies, such as SILAC and TMT protein labeling are powerful methods for identifying a large number of novel biomarkers. Chapter 2 describes a MALDI-TOF/TOF based proteomic approach to profile HAPE-related proteomic changes in plasma. 25 differential plasma proteins responsible for the discrimination..