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Nanoparticles in Life Sciences and Biomedicine

Nanoparticles in Life Sciences and Biomedicine

The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles such as nanoemulsions liposomes nanocrystals and nanocomplexes applied in the diagnosis treatment or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and following a multidisciplinary approach presents new strategies for drug delivery including aspects from chemistry physics biology and imaging methodologies and exploiting several administration routes internalization pathways site-specific delivery strategies and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy the book moves on to detailing oral topical pulmonary brain cancer and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly it is suitable for advanced undergraduate graduate and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience nanotechnology chemistry biology biochemistry pharmaceutical sciences medicine and bioengineering especially those with an interest in drug delivery or theranostics; and academia and university readership. | Nanoparticles in Life Sciences and Biomedicine

GBP 139.00
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Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer β-Lactams and related compounds as antibacterials non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy. | Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

GBP 193.00
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Three Daughters Three Journeys Quest for Cancer Cure

Three Daughters Three Journeys Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women in particular are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60 these inheritable cancers threaten women’s lives health and fertility even when they are young before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena a Polish oncology nurse has spent her life treating child patients with cancer. Then she confronts it in her own family and her own body. Kamola a rural Indian girl knows she has symptoms of the same disease that took her mother but feels afraid to discuss it with her father and brothers knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra a doctor testing a new treatment called Neelazin using a bacterial anticancer protein in food to destroy cancer cells. Selena a wealthy woman of color in Chicago finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs as these drugs can enter both normal and cancer cells though preferably cancer cells causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets thereby becoming resistant to the drugs as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer rather than removing the healthy tissue of the breasts and ovaries. Hopefully they would not have to choose between fertility and survival as is the implied message in this book fictional as it is at this time. | Three Daughters Three Journeys Quest for Cancer Cure

GBP 31.99
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