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Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction purification and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different methods. The book also discusses the development of antibodies and immunochemical techniques as tools for characterizing proteins and modified proteins such as glycoproteins. Helpful illustrations diagrams and tables effectively transform theoretical concepts into practical knowledge. Along with methodical working procedures for most techniques the book also offers useful advice on which technique to use and when to apply a particular method. Presenting the advantages and disadvantages of the various protein techniques Principles and Reactions of Protein Extraction Purification and Characterization enables students and researchers to master the mechanisms behind the protocols and choose the best method for their purposes.

GBP 205.00
1

Power Systems Handbook - Four Volume Set

Power Systems Handbook - Four Volume Set

This handbook on power systems consists of a set of 4 volumes. These books are carefully planned and designed to provide the state of art material on major aspects of electrical power systems short-circuit currents load flow harmonics and protective relaying. Many aspects of power systems are transparent between different types of studies and analyses; knowledge of short-circuit currents and symmetrical component is required for protective relaying and fundamental frequency load flow is required for harmonic analysis. Currently power systems large or small are analyzed on digital computers with appropriate software. However it is necessary to understand the theory and basis of these calculations to debug and decipher the results. The material is organized with sound theoretical base practical applications and case studies based on the author’s 45+ years of experience with real world problems. | Power Systems Handbook - Four Volume Set

GBP 190.00
1

Audio Power Amplifier Design

Audio Power Amplifier Design

This is the essential book reference for amplifier designers. Douglas Self covers all the design issues of noise distortion power supply rejection protection reliability and layout. He describes advanced forms of compensation that give dramatically lower distortion. This edition is much expanded and packed with new information. It is a must-have for audio power amplifier professionals and audiophiles amateur constructors and anyone with intellectual curiosity about the struggle towards technical excellence. New to the sixth edition: The characteristics of the audio signal The principles of distortion Feedback intermodulation distortion Non-switching output stages VAS distortion explained Push-pull VAS configurations Output-inclusive compensation In addition five amplifier design examples that illustrate important design principles are examined and measured in detail. These can be straightforwardly adapted to specific requirements. This new edition also includes a wealth of material on the XD crossover-displacement principle (invented by the author and in use by Cambridge Audio) four-stage amplifier architectures error correction current-mirrors power transistors with internal sensing diodes amplifier bridging input-stage-common-mode distortion amplifier stability output stages with gain inrush current suppression DC servo design thermal protection cooling fan control advanced line input stages testing and safety infrared remote control signal activation 12V trigger control the history of solid-state amplifiers and much more. Simple procedures for heatsinking and power supply design are given. | Audio Power Amplifier Design

GBP 180.00
1

A Concise Introduction to Pure Mathematics

A Concise Introduction to Pure Mathematics

Accessible to all students with a sound background in high school mathematics A Concise Introduction to Pure Mathematics Fourth Edition presents some of the most fundamental and beautiful ideas in pure mathematics. It covers not only standard material but also many interesting topics not usually encountered at this level such as the theory of solving cubic equations; Euler‘s formula for the numbers of corners edges and faces of a solid object and the five Platonic solids; the use of prime numbers to encode and decode secret information; the theory of how to compare the sizes of two infinite sets; and the rigorous theory of limits and continuous functions. New to the Fourth Edition Two new chapters that serve as an introduction to abstract algebra via the theory of groups covering abstract reasoning as well as many examples and applications New material on inequalities counting methods the inclusion-exclusion principle and Euler‘s phi function Numerous new exercises with solutions to the odd-numbered ones Through careful explanations and examples this popular textbook illustrates the power and beauty of basic mathematical concepts in number theory discrete mathematics analysis and abstract algebra. Written in a rigorous yet accessible style it continues to provide a robust bridge between high school and higher-level mathematics enabling students to study more advanced courses in abstract algebra and analysis.

GBP 180.00
1

Intracellular Calcium-Dependent Proteolysis

Intracellular Calcium-Dependent Proteolysis

Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains which are intracellular non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed including their potential roles in muscle protein turnover platelet activation membrane fusion and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

GBP 180.00
1

Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

This book includes all the papers presented at the meeting revised to take account of all the points made during discussions and the Consensus Statement itself. The topics covered include recommendations for optimum carbohydrate protein fat total energy fluid and electrolyte and vitamin mineral intakes to maximise sports performance. | Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

GBP 180.00
1

Uses of Elemental Diets in Clinical Situations

Uses of Elemental Diets in Clinical Situations

The studies presented in this book demonstrate that a new concept in the management of carious intestinal disorders should be considered namely that common nutrients may protect or heal the mucosa by virtue of the particular form and mode in which they are delivered to the intestinal lumen and their availability to the mucosal cells. The substitution of intact protein in the formula by hydrolysate appears to me an important factor. | Uses of Elemental Diets in Clinical Situations

GBP 205.00
1

Networks of Influence and Power Business Culture and Identity in Liverpool's Merchant Community c.1800 to 1914

Networks of Influence and Power Business Culture and Identity in Liverpool's Merchant Community c.1800 to 1914

During the nineteenth century Liverpool became the heart of an international maritime network. As the 'second city' of Empire its merchants and shipowners operated within a transnational commercial and financial system while its trading connections stimulated the development of new markets and their integration within an increasingly global economy. This ground-breaking volume brings together ten original contributions that reflect upon the development of the city's business community from the early-nineteenth century to the outbreak of the First World War with an emphasis on the period from 1851 to 1912. It offers the first detailed analysis of Liverpool's merchant community within a conceptual and historiographical framework which focuses on the economic social and cultural role of business elites in the nineteenth century. It explores the extent to which business success was predicated on the maintenance of networks of trust; analyses the importance of business culture in structuring commercial operations; and discusses the role of ethics trust and reputation within the changing framework of the business environment. Particular attention is paid to the role of women and the important contribution of the family to commercial success and the maintenance of social networks. Changes in business practice and social networks are also examined within a spatial context in order to assess the impact of the development of a distinct commercial centre and the clustering of commercial activity on interaction reputation and trust while particular attention is paid to the effect of suburbanization on existing associational networks the social cohesiveness of business culture and the cultural identity of the merchant community as a whole. | Networks of Influence and Power Business Culture and Identity in Liverpool's Merchant Community c. 1800 to 1914

GBP 205.00
1

Statistical Modeling and Machine Learning for Molecular Biology

Statistical Modeling and Machine Learning for Molecular Biology

Molecular biologists are performing increasingly large and complicated experiments but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs ortholog identification motif finding inference of population structure protein fold prediction and many more. The book takes a pragmatic approach focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics. | Statistical Modeling and Machine Learning for Molecular Biology

GBP 180.00
1

Principles of Sustainable Energy Systems Third Edition

Principles of Sustainable Energy Systems Third Edition

PRINCIPLES OF SUSTAINABLE ENERGY SYSTEMS Third Edition surveys the range of sustainable energy sources and the tools that engineers scientists managers and policy makers use to analyze energy generation usage and future trends. The text provides complete and up-to-date coverage of all renewable technologies including solar and wind power biofuels hydroelectric nuclear ocean power and geothermal energy. The economics of energy are introduced with the SAM software package integrated so students can explore the dynamics of energy usage and prediction. Climate and environmental factors in energy use are integrated to give a complete picture of sustainable energy analysis and planning.

GBP 180.00
1

Receptor Phosphorylation

Receptor Phosphorylation

The following chapters comprise invited contributions from eminent scientists who are internationally recognized authorities on the subject. The chapters have been written to provide the reader with adequate background necessary experimental details and discussion that is easy to comprehend. The book has been organized into four different sections. The introductory chapter is meant to briefly summarize the contributions of other authors and discuss phosphorylation of receptor systems not covered in the book in detail. The chapters in the second section on protein kinases and phosphatases are quite fundamental to the process of phosphorylation and will aid the reader in appreciating the observations and discussions reported in other chapters. The third and fourth sections present discussions on phosphorylation of various receptor systems which are involved in mediating actions of peptide amine and steroid hormones. It is hoped that this book will serve as a valuable resource and will be useful to all workers and students in the area of receptor-ligand interactions. | Receptor Phosphorylation

GBP 205.00
1

Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials scientists learn how to use PK/PD seamlessly in a variety of practical areas from simple plasma kinetics multi-compartment models nonlinear kinetics plasma protein binding pharmacodynamic models turnover concepts receptor binding functional adaption and rebound dose-response-time data analysis inter-species scaling and a lot more. A substantial effort has been invested into the new pharmacokineticsand pharmacodynamics including many new and updated Case Studies. The text develops a logical real-world approach to data and reasoning showing the reader how to: Think both analytically and visually about data Use graphics to make a point Impove your pattern recognition ability Make sound decisions Strategize your data analyses Appreciate more fully the exciting field of Quantitative Pharmacology | Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

GBP 200.00
1

Organelle and Molecular Targeting

Organelle and Molecular Targeting

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA DNA and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines reducing the required dose and therefore the biomanufacturing demand. Likewise improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies cancer neurodegeneration progerias diabetes and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status demand and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students scientists and clinicians contributing to modern medicine.

GBP 200.00
1

Self Assembly The Science of Things That Put Themselves Together

Self Assembly The Science of Things That Put Themselves Together

Hailed as one of the key areas of nanoscience likely to shape future scientific research self-assembly offers the most promising route to true molecular nanotechnology. Focusing on this dynamic new field Self Assembly: The Science of Things That Put Themselves Together explores nature's self-assembly of structures the use of it to build engineered systems and the latest advances in the field. Reflecting the inherent progress of the science of self-assembly this definitive book first delves into natural self-assembling systems. It addresses crystal growth soap films and micelles; examines how nature builds viruses proteins and ribosomes; and introduces the protein folding problem. The author then discusses how physicists chemists biologists and engineers are applying nature's principles to self-assemble everything from DNA cubes to millimeter-scale electronic circuits. The final chapters cover theoretical and experimental approaches to understand the phenomenon of self-assembly and overcome its various challenges. With practical activities profiles of leading experts chapter highlights exercises and references Self Assembly provides the most current authoritative information on this exciting branch of nanoscience. | Self Assembly The Science of Things That Put Themselves Together

GBP 180.00
1

Automation and Computation Proceedings of the International Conference on Automation and Computation (AutoCom 2022) Dehradun India

Automation and Computation Proceedings of the International Conference on Automation and Computation (AutoCom 2022) Dehradun India

The proceedings of the International Conference on Automation and Computation 2022 (AUTOCOM-22) consist of complete research articles that were presented at the conference. Each of the research articles was double-blind reviewed by the experts of the corresponding domain. The book contains a blend of problems and respective solutions related to computer-based automation & computation to highlight the recent technological developments in computer-based automation. It serves as an environment for researchers to showcase the latest research results on Data Science & Engineering Computing Technologies Computational Intelligence Communication & Networking Signal & Image Processing Intelligent Control Systems & Optimization Robotics and Automation Power Energy & Power Electronics Healthcare & Computation AI for human interaction etc. It aims to give deep insight into the current trends of research in science and technology and shall introduce the reader to the new problems and respective approaches toward the solution and shall enlighten the researchers students and academicians about the research being carried out in the field. | Automation and Computation Proceedings of the International Conference on Automation and Computation (AutoCom 2022) Dehradun India

GBP 250.00
1

The Routledge Handbook of Sociolinguistics Around the World

The Routledge Handbook of Sociolinguistics Around the World

Drawing on examples from a wide range of languages and social settings The Routledge Handbook of Sociolinguistics Around the World was originally the first single-volume collection surveying the current research trends in international sociolinguistics. This new edition has been comprehensively updated and significantly expanded and now includes more than 50 chapters written by leading authorities and a brand-new substantial introduction by John Edwards. Coverage has been expanded regionally and there is a critical focus on Indigenous languages. This handbook remains a key tool to help widen the perspective on sociolinguistics to readers interested in the field. Divided into sections covering the Americas Asia Australasia Africa and Europe the book provides readers with a solid up-to-date appreciation of the interdisciplinary nature of the field of sociolinguistics in each area. It clearly explains the patterns and systematicity that underlie language variation in use along with the ways in which alternations between different language varieties mark personal style social power and national identity. The Routledge Handbook of Sociolinguistics Around the World is the ideal resource for all students in undergraduate sociolinguistics courses and for researchers involved in the study of language society and power.

GBP 205.00
1

Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

Bioactive peptides have been receiving attention recently due to their applications as health-promoting agents. Derived from food proteins and other natural sources they exhibit various beneficial effects such as preventing diseases or modulating physiological systems once absorbed. As the market for nutraceuticals and functional foods continues to expand consumer interest has also grown and there are many common foods that have shown an abundance of bioactive peptides including dairy products cereal legumes meat and numerous other sources. In this newest addition to the series Nutraceuticals: Basic Research and Clinical Applications Bioactive Peptides: Production Bioavailability Health Potential and Regulatory Issues provides a comprehensive review of the current state of knowledge in the field of food protein hydrolysates and bioactive peptides their food sources bioavailability production applications functionalities health potentials and regulatory issues governing their use. Features Discusses different methodologies employed for scaling up bioactive peptides commercially Provides information on optimizing the production process Explains various bioactive properties exerted by different types of bioactive peptides Explores the application of metabolomics to the study of bioactive peptides With over 20 chapters written by established subject matter experts in their field this book provides timely information and discusses the latest developments of bioactive peptides. It will be useful for researchers academics and industry experts and can serve as an excellent resource for anyone interested in enhancing their knowledge in the field of bioactive peptides. | Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

GBP 190.00
1

The Routledge Handbook of Language and Youth Culture

The Routledge Handbook of Language and Youth Culture

The Routledge Handbook of Language and Youth Culture offers the first essential grounding of critical youth studies within sociolinguistic research. Young people are often seen to be at the frontline of linguistic creativity and pioneering communicative technologies. Their linguistic practices are considered a primary means of exploring linguistic change as well as the role of language in social life such as how language and identity ideology and power intersect. Bringing together leading and cutting-edge perspectives from thought leaders across the globe this handbook: addresses how young people’s cultural practices as well as forces like class gender ethnicity and race influence language considers emotions affect age and ageism materiality embodiment and the political youth as well as processes of unmooring language and place critically reflects on our understandings of terms such as ‘language’ ‘youth’ and ‘culture’ drawing on insights from youth studies to help contextualise age within power dynamics features examples from a wide range of linguistic contexts such as social media and the classroom as well as expressions such as graffiti gestures and different musical genres including grime and hip-hop Providing important insights into how young people think feel act and communicate in the complexity of a polarised world The Routledge Handbook of Language and Youth Culture is an invaluable resource for advanced students and researchers in disciplines including sociolinguistics linguistic anthropology multilingualism youth studies and sociology.

GBP 205.00
1

The Routledge Handbook of Public Taxation in Medieval Europe

The Routledge Handbook of Public Taxation in Medieval Europe

Beginning in the twelfth century taxation increasingly became an essential component of medieval society in most parts of Europe. The state-building process and relations between princes and their subject cities or between citizens and their rulers were deeply shaped by fiscal practices. Although medieval taxation has produced many publications over the past decades there remains no synthesis of this important subject. This volume provides a comprehensive overview on a European scale and suggests new paths of inquiry. It examines the fiscal systems and practices of medieval Europe including essential themes such as medieval fiscal theory and the power to tax; royal and urban taxation; and Church taxation. It goes on to survey the entire European continent as well as including comparative chapters on the non-European medieval world exploring questions on how taxation developed and functioned; what kinds of problems authorities encountered assessing their fiscal power; and the circulation of fiscal cultures and practices across cities and kingdoms. The book also provides a glossary of the most important types of medieval taxes giving an essential definition of key terms cited in the chapters. The Routledge Handbook of Public Taxation in Medieval Europe will appeal to a large audience from seasoned scholars who need a comprehensive synthesis to students and younger scholars in search of an overview of this critical subject.

GBP 190.00
1

Error Correcting Codes A Mathematical Introduction

Error Correcting Codes A Mathematical Introduction

Assuming little previous mathematical knowledge Error Correcting Codes provides a sound introduction to key areas of the subject. Topics have been chosen for their importance and practical significance which Baylis demonstrates in a rigorous but gentle mathematical style. Coverage includes optimal codes; linear and non-linear codes; general techniques of decoding errors and erasures; error detection; syndrome decoding and much more. Error Correcting Codes contains not only straight maths but also exercises on more investigational problem solving. Chapters on number theory and polynomial algebra are included to support linear codes and cyclic codes and an extensive reminder of relevant topics in linear algebra is given. Exercises are placed within the main body of the text to encourage active participation by the reader with comprehensive solutions provided. Error Correcting Codes will appeal to undergraduate students in pure and applied mathematical fields software engineering communications engineering computer science and information technology and to organizations with substantial research and development in those areas. | Error Correcting Codes A Mathematical Introduction

GBP 180.00
1

The International Directory of Government 2019

The International Directory of Government 2019

The International Directory of Government is the definitive guide to people in power in every part of the world. All the top decision-makers are included in this one-volume publication which brings together government institutions agencies and personnel from the largest nations (China India Russia etc. ) to the smallest overseas dependencies (Guadeloupe Guernsey and Christmas Island etc). Institutional entries contain the names and titles of principal officials postal e-mail and internet addresses telephone and fax numbers and other relevant details. Key features: - comprehensive lists of government ministers and ministries - coverage of state-related agencies and other institutions arranged by subject heading - details of important state provincial and regional administrations including information on US states Russian republics and the states and territories of India. | The International Directory of Government 2019

GBP 270.00
1

Handbook of Brewing

Handbook of Brewing

With a foreword written by Professor Ludwig Narziss—one of the world’s most notable brewing scientists—the Handbook of Brewing Third Edition as it has for two previous editions provides the essential information for those who are involved or interested in the brewing industry. The book simultaneously introduces the basics—such as the biochemistry and microbiology of brewing processes—and also deals with the necessities associated with a brewery which are steadily increasing due to legislation energy priorities environmental issues and the pressures to reduce costs. Written by an international team of experts recognized for their contributions to brewing science and technology it also explains how massive improvements in computer power and automation have modernized the brewhouse while developments in biotechnology have steadily improved brewing efficiency beer quality and shelf life.

GBP 180.00
1