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Protein Purification

Protein Purification

This second edition of Protein Purification provides a guide to the major chromatographic techniques including non-affinity absorption techniques affinity procedures non-absorption techniques and methods for monitoring protein purity. The new edition of the book has been organized to encourage incremental learning about the topic starting with the properties of water progressing through the characteristics of amino acids and proteins which relate to the purification process. There is an overview of protein strategy and equipment followed by discussions and examples of each technique and their applications. The basic theory and simple explanations given in Protein Purification make it an ideal handbook for final year undergraduates and postgraduates who are conducting research projects. It will also be a useful guide to more experienced researchers who need a good overview of the techniques and products used in protein purification. Key Features * Guide to the major techniques used in protein purification * Includes flowcharts to help the reader slect the best purification strategy * Contains step-by-step protocols that guide the reader through each technique and its use * Includes exercises and solutions

GBP 66.99
1

The Protein Folding Problem

The Protein Folding Problem

Proteins in living systems carry out a great variety of specific functions each of which depends on the precise three-dimensional structure of a particular protein. Proteins are synthesized in the form of a flexible polypeptide chain that is capable of assuming a vast number of configurations; the transformation of this chain into a specific relatively rigid three-dimensional structure is called folding-a remarkable process of self-organization. It is known that the amino acid sequences of some proteins have sufficient information to determine their three-dimensional structures. There are other proteins whose folding requires additional information beyond that found in the sequence of the mature protein. This book introduces the central problem of folding mechanisms as well as a number of other closely related issues. This book is neither a textbook nor a treatise. Rather it is an attempt by several investigators to convey the excitement and challenges of those aspects of the folding problem in which they are actively engaged. The contributors give brief introductions to protein folding from the perspectives of molecular architecture stability and dynamics phage genetics DNA exons general physiology and natural selection. They point out emerging new directions including the suggestion of a class of diseases that result from protein folding defects. | The Protein Folding Problem

GBP 130.00
1

Protein Actions Principles and Modeling

Protein Actions Principles and Modeling

Protein Actions: Principles and Modeling is aimed at graduates advanced undergraduates and any professional who seeks an introduction to the biological chemical and physical properties of proteins. Broadly accessible to biophysicists and biochemists it will be particularly useful to student and professional structural biologists and molecular biophysicists bioinformaticians and computational biologists biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics energetics and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science. | Protein Actions Principles and Modeling

GBP 99.99
1

The Fluorescent Protein Revolution

The Fluorescent Protein Revolution

Advances in fluorescent proteins live-cell imaging and superresolution instrumentation have ushered in a new era of investigations in cell biology medicine and physiology. From the identification of the green fluorescent protein in the jellyfish Aequorea victoria to the engineering of novel fluorescent proteins The Fluorescent Protein Revolution explores the history properties and applications of these important probes. The book first traces the history of fluorescent proteins and the revolution they enabled in cellular imaging. It then discusses fluorescent proteins with novel photophysical properties. The book also covers several cutting-edge imaging applications. These include superresolution microscopy of cellular fine structures FRET microscopy to visualize protein interactions and cell-signaling activities inside living cells photobleaching and photoactivation techniques to visualize protein behaviors techniques that exploit plant and algal photoreceptors to enable light-regulated control of enzymatic activities and the noninvasive imaging of tumor–host interactions in living animals. In color throughout this book presents the fundamental principles and latest advances in the field including the associated development of imaging techniques that exploit fluorescent proteins. It is accessible to a broad audience from optical imaging experts to novices needing an introduction to the field.

GBP 59.99
1

Peptide and Protein Drug Analysis

Peptide and Protein Drug Analysis

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad comprehensive overview of peptides and proteins as mediators of cell movement proliferation differentiation and communication. Written by more than 50 leading international authorities Peptides and Protein Drug Analysisdiscusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic capillary electrophoretic gel electrophoretic and isoelectric focusing methods highlights drug design elements derived from protein folding bioinformatics and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry protein sequence and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet fluorescence Fourier transform infrared and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light X-ray and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables equations and illustrations Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical organic and pharmaceutical chemis

GBP 59.99
1

Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction purification and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different methods. The book also discusses the development of antibodies and immunochemical techniques as tools for characterizing proteins and modified proteins such as glycoproteins. Helpful illustrations diagrams and tables effectively transform theoretical concepts into practical knowledge. Along with methodical working procedures for most techniques the book also offers useful advice on which technique to use and when to apply a particular method. Presenting the advantages and disadvantages of the various protein techniques Principles and Reactions of Protein Extraction Purification and Characterization enables students and researchers to master the mechanisms behind the protocols and choose the best method for their purposes.

GBP 205.00
1

Novel Plant Protein Processing Developing the Foods of the Future

Novel Plant Protein Processing Developing the Foods of the Future

Proteins serve as an important nutritional as well as structural component of foods. Not only do they provide an array of amino acids necessary for maintaining human health but also act as thickening stabilizing emulsifying foaming gelling and binding agents. The ability of a protein to possess and demonstrate such unique functional properties depends largely on its inherent structure configuration and how they interact with other food constituents like polysaccharides lipids and polyphenolic compounds. Proteins from animal sources have superior functionality higher digestibility and lower anti-nutrient components than plant proteins. However consumer preferences are evolving worldwide for ethically and sustainably sourced clean cruelty-free vegan or vegetarian plant-based food products. Unlike proteins from animal sources plant proteins are more versatile religiously and culturally acceptable among vegetarian and vegan consumers and associated with lower food processing waste water and soil requirement. Thus the processing and utilization of plant proteins have gained worldwide attention and as such numerous scientific studies are focusing on enhancing the utilization of plant proteins in food and pharmaceutical products through various processing and modification techniques to improve their techno-functional properties bioactivity bioavailability and digestibility. Novel Plant Protein Processing: Developing the Foods of the Future presents a roadmap for plant protein science and technology which will focus on plant protein ingredient development plant protein modification and the creation of plant protein-based novel foods. Key Features: Includes complete information about novel plant protein processing for use as future foods Presents a roadmap to upscale the meat analog technological processes Discusses marketing limitations of plant based proteins and future opportunities This book highlights the important scientific technological advancements that are being deployed in the future foods using plant proteins concerns opportunities and challenges and as an alternative to maintaining a healthy and sustainable modern food supply. It covers the most recent research related to the plant protein-based future foods which include their extraction isolation modification characterization development and final applications. It also covers the formulation and challenges: emphasis on the modification for a specific use legal aspects business perspective and future challenges. This book is useful for researchers readers scientists and industrial people to find information easily. | Novel Plant Protein Processing Developing the Foods of the Future

GBP 170.00
1

Computational Approaches to Protein Dynamics From Quantum to Coarse-Grained Methods

Computational Approaches to Protein Dynamics From Quantum to Coarse-Grained Methods

The Latest Developments on the Role of Dynamics in Protein Functions Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry physics and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs) which lack a well-defined three-dimensional structure and function as dynamic ensembles. The book covers a wide spectrum of dynamics from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies the book addresses the following issues: Is there a quantitative relationship between enzymatic catalysis and protein dynamics? Which are the functionally relevant motions of proteins? How can structural properties and partner recognition mechanisms of IDPs be simulated? How can we speed up molecular dynamics? How can we describe conformational ensembles by the synergistic effort of computations and experiments? While dynamics is now considered essential for interpreting protein action it is not yet an integral component in establishing structure–function relationships of proteins. Helping to reshape this classical view in biochemistry this groundbreaking book explores advances in computational methodology and contributes to the new ensemble way of studying proteins. | Computational Approaches to Protein Dynamics From Quantum to Coarse-Grained Methods

GBP 69.99
1

Power Quality

Power Quality

Frequency disturbances transients grounding interference…the issues related to power quality are many and solutions to power quality problems can be complex. However by combining theory and practice to develop a qualitative analysis of power quality the issues become relatively straightforward and one can begin to find solutions to power quality problems confronted in the real world. Power Quality builds the foundation designers engineers and technicians need to survive in the current power system environment. It treats power system theory and power quality principles as interdependent entities and balances these with a wealth of practical examples and data drawn from the author's 30 years of experience in the design testing and trouble-shooting of power systems. It compares different power quality measurement instruments and details ways to correctly interpret power quality data. It also presents alternative solutions to power quality problems and compares them for feasibility and economic viability. Power quality problems can have serious consequences from loss of productivity to loss of life but they can be easily prevented. You simply need a good understanding of electrical power quality and its impact on the performance of power systems. By changing the domain of power quality from one of theory to one of practice this book imparts that understanding and will develop your ability to effectively measure test and resolve power quality problems.

GBP 59.99
1

Power Quality in Power Distribution Systems Concepts and Applications

Power Quality in Power Distribution Systems Concepts and Applications

The comprehensive textbook will help readers to develop analytic reasoning of power quality aspects in distribution power systems. It will as an ideal study material for senior undergraduate and graduate students in the field of electrical engineering electronics and communications engineering. • Provides explanation of transformations and power theories for single phase and three-phase systems. • Discusses concepts illustrating power quality aspects in power distribution network. • Examines detailed derivations and analysis of voltage and current compensation techniques. • Discusses custom power devices such as DSTATCOM DVR and UPQC. • Presents solved examples theoretical and numerical exercises in each chapter. This textbook comprehensively covers fundamentals concepts of power quality with the help of solved problems. It provides basic understanding of power quality aspects in power systems especially in power distribution networks and explains issues related to power quality problems their quantification analysis and interpretation. It covers important topics including single phase circuits three phase circuits theory of fundamental load compensation instantaneous reactive power theory theory of instantaneous symmetrical components dynamic voltage restorer (DVR) and unified power quality conditioner. Pedagogical features including solved problems and unsolved exercises are interspersed throughout the text for better understanding. The textbook is primarily written for senior undergraduate and graduate students in the field of electrical engineering electronics and communications engineering for courses on power quality/power system/power electronics. The textbook will be accompanied by teaching resource including solution manual for the instructors. | Power Quality in Power Distribution Systems Concepts and Applications

GBP 110.00
1

DC Power Supplies Power Management and Surge Protection for Power Electronic Systems

DC Power Supplies Power Management and Surge Protection for Power Electronic Systems

As we increasingly use electronic devices to direct our daily lives so grows our dependence on reliable energy sources to power them. Because modern electronic systems demand steady efficient reliable DC voltage sources—often at a sub-1V level—commercial AC lines batteries and other common resources no longer suffice. New technologies also require intricate techniques to protect against natural and manmade disasters. Still despite its importance practical information on this critical subject remains hard to find. Using simple accessible language to balance coverage of theoretical and practical aspects DC Power Supplies Power Management and Surge Protection details the essentials of power electronics circuits applicable to low-power systems including modern portable devices. A summary of underlying principles and essential design points it compares academic research and industry publications and reviews DC power supply fundamentals including linear and low-dropout regulators. Content also addresses common switching regulator topologies exploring resonant conversion approaches. Coverage includes other important topics such as: Control aspects and control theory Digital control and control ICs used in switching regulators Power management and energy efficiency Overall power conversion stage and basic protection strategies for higher reliability Battery management and comparison of battery chemistries and charge/discharge management Surge and transient protection of circuits designed with modern semiconductors based on submicron dimension transistors This specialized design resource explores applicable fundamental elements of power sources with numerous cited references and discussion of commercial components and manufacturers. Regardless of their previous experience level this information will greatly aid designers researchers and academics who study design and produce the viable new power sources needed to propel our modern electronic world. | DC Power Supplies Power Management and Surge Protection for Power Electronic Systems

GBP 74.99
1

Power System Capacitors

Power System Capacitors

Since transmitting reactive power over long distances is not feasible power systems integrate power factor correction capacitors to provide local reactive power compensation. With a wide range of options available and with the tremendous changes that have occurred over the past few decades a comprehensive up-to-date book on power factor capacitors is long overdue. Power System Capacitors fills this void by providing the fundamentals applications protection issues and system impacts for a broad spectrum of capacitor applications. Power System Capacitors guides you through the practical installations with easy-to-follow step-by-step instructions. The author describes the fundamentals of capacitors focused on the power factor correction industry standards capacitor specifications protection of shunt capacitors maintenance of capacitor banks and system impact issues. He also discusses the selection of supporting equipment such as fuses circuit breakers and surge arresters; includes more than 290 illustrations 90 tables and 400 equations; and explains how to perform an economic analysis. Offering up-to-date computer-aided analysis approaches along with fundamental concepts maintenance concerns and economic analysis Power System Capacitors steers you through the selection design installation and maintenance of power factor correction capacitors used in modern power systems. This is a valuable tool for any power system engineer in industry utilities consulting and practical power system evaluation.

GBP 59.99
1

Switching Power Converters Medium and High Power Second Edition

Switching Power Converters Medium and High Power Second Edition

An examination of all of the multidisciplinary aspects of medium- and high-power converter systems including basic power electronics digital control and hardware sensors analog preprocessing of signals protection devices and fault management and pulse-width-modulation (PWM) algorithms Switching Power Converters: Medium and High Power Second Edition discusses the actual use of industrial technology and its related subassemblies and components covering facets of implementation otherwise overlooked by theoretical textbooks. The updated Second Edition contains many new figures as well as new and/or improved chapters on: Thermal management and reliability Intelligent power modules AC/DC and DC/AC current source converters Multilevel converters Use of IPM within a network of switches concept Power semiconductors Matrix converters Practical aspects in building power converters Providing the latest research and development information along with numerous examples of successful home appliance aviation naval automotive electronics industrial motor drive and grid interface for renewable energy products this edition highlights advancements in packaging technologies tackles the advent of hybrid circuits able to incorporate control and power stages within the same package and examines design for reliability from the system level perspective. | Switching Power Converters Medium and High Power Second Edition

GBP 94.99
1

Telecom Power Systems

Telecom Power Systems

This book addresses topics specific to the application of power electronics to telecom systems. It follows the power flow from national grid down to the last low-voltage high current requirement of a processor. Auxiliary equipment requirements such as uninterruptible power supplies storage energy systems or charging systems are explained along with peculiar classification or suggestions for usage. The presentation of each telecom power system is completed with a large number of practical examples to reinforce new material. | Telecom Power Systems

GBP 48.99
1

Elements of Power Systems

Elements of Power Systems

Elements of Power Systems prepares students for engineering degrees diplomas Associate Member of the Institution of Engineers (AMIE) examinations or corresponding examinations in electrical power systems. Complete with case studies worked examples and circuit schematic diagrams this comprehensive text: Provides a solid understanding of the theoretical aspects of power system engineering Instills a practical knowledge of large-scale power system analysis techniques Covers load characteristics tariffs power system stability and more Elements of Power Systems is designed as an undergraduate-level textbook but the book also makes a handy reference for practicing power engineers.

GBP 66.99
1

Spacecraft Power Systems

Spacecraft Power Systems

This second edition of Spacecraft Power Systems is a comprehensive coverage of the fundamentals design trades components controls and operations of spacecraft power systems based on the real-world design and operations of spacecraft that have successfully flown for decades. It also includes emerging high-voltage high-power systems for in-space propulsion for interplanetary travel. With new and updated chapters sections and discussions the second edition covers up-to-date high-voltage MW-scale electric propulsion updated PV and battery systems spacecraft power components power electronics and their architectures and operations. This book also presents the latest in spacecraft design processes and trades controls operations and protection. This book is intended for senior undergraduate and graduate students in mechanical aerospace and electrical engineering taking courses in Space Systems Space Engineering and Spacecraft Power Systems as well as for practicing aerospace and power engineers and managers who are designing developing and operating spacecraft power systems.

GBP 145.00
1

Power Engineering Advances and Challenges Part B: Electrical Power

Power Engineering Advances and Challenges Part B: Electrical Power

Traditionally power engineering has been a subfield of energy engineering and electrical engineering which deals with the generation transmission distribution and utilization of electric power and the electrical devices connected to such systems including generators motors and transformers. Implicitly this perception is associated with the generation of power in large hydraulic thermal and nuclear plants and distributed consumption. Faced with the climate change phenomena humanity has had to now contend with changes in attitudes in respect of environment protection and depletion of classical energy resources. These have had consequences in the power production sector already faced with negative public opinions on nuclear energy and favorable perception of renewable energy resources and about distributed power generation. The objective of this edited book is to review all these changes and to present solutions for future power generation. Future energy systems must factor in the changes and developments in technology like improvements of natural gas combined cycles and clean coal technologies carbon dioxide capture and storage advancements in nuclear reactors and hydropower renewable energy engineering power-to-gas conversion and fuel cells energy crops new energy vectors biomass-hydrogen thermal energy storage new storage systems diffusion modern substations high voltage engineering equipment and compatibility HVDC transmission with FACTS advanced optimization in a liberalized market environment active grids and smart grids power system resilience power quality and cost of supply plug-in electric vehicles smart metering control and communication technologies new key actors as prosumers smart cities. The emerging research will enhance the security of energy systems safety in operation protection of environment improve energy efficiency reliability and sustainability. The book reviews current literature in the advances innovative options and solutions in power engineering. It has been written for researchers engineers technicians and graduate and doctorate students interested in power engineering. | Power Engineering Advances and Challenges Part B: Electrical Power

GBP 44.99
1

Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials

Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials

Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials provides a practical introduction to unconditional approaches to planning randomised clinical trials particularly aimed at drug development in the pharmaceutical industry. This book is aimed at providing guidance to practitioners in using average power assurance and related concepts. This book brings together recent research and sets them in a consistent framework and provides a fresh insight into how such methods can be used. Features: A focus on normal theory linking average power expected power predictive power assurance conditional Bayesian power and Bayesian power. Extensions of the concepts to binomial and time-to-event outcomes and non-inferiority trials An investigation into the upper bound on average power assurance and Bayesian power based on the prior probability of a positive treatment effect Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program or to the successful outcome of an interim analysis Prior distribution of power and sample size Extension of the basic approach to proof-of-concept trials with dual success criteria Investigation of the connection between conditional and predictive power at an interim analysis and power and assurance Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect and an unconditional version.

GBP 99.99
1